Spatial multi-omics reveals cell-type-specific nuclear compartments A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments in the mouse brain. Yodai Takei , Yujing...
Such insight into the underlying relationship between OMICs and cellular behaviors leads us to better neurological and psychiatric therapeutics by intelligently designing and utilizing the CRISPR/Cas9 technology.doi:10.1016/j.ijbiomac.2024.130413Banazadeh, Mohammad...
These pages contain links to raw and processed data hosted on the Neuroscience Multi-Omic data archive under the identifier dat-717krsa (https://assets.nemoarchive.org/dat-717krsa). All data supporting the findings of this study are provided within the paper and its Supplementary Information. ...
multiomics(多组学) spatial genomics(空间基因组学) middle temporal gyrus(中颞回) 研究背景 阿尔茨海默病(AD)是老年人痴呆的主要原因,尽管AD进展特征为蛋白质病理的刻板积累,但受影响的细胞群体研究不足。 单细胞和空间基因组学技术现在可以提供对复杂脑组织的高分辨率分析,有助于识别AD中的细胞脆弱性和分子变化。
Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy Synaptic vesicle dysfunction in Parkinson’s disease is unexplored. Here, using electron microscopy, lipidomic and proteomic analyses, Gao et al. provide insights into synaptic vesicle biology and disease mechanisms. ...
Du Y, Tan W-L, Chen L, Yang Z-M, Li X-S, Xue X, Cai Y-S, Cheng Y (2021b) Exosome transplantation from patients with schizophrenia causes schizophrenia-relevant behaviors in mice: an integrative multi-omics data analysis. Schizophr Bull 47(5):1288–1299. https://doi.org/10.1093/sch...
Employing multi-omics to elucidate the hormetic response against oxidative stress exerted by nC(60) on Daphnia pulex. Environ Pollut. 2019;251:22–9. CAS PubMed Google Scholar Salles MS, Salles KS. Behavioral effect of selective and non-selective lesions of median raphe nucleus in the rat. ...
EVERYTHING YOU HAVE BEEN TOLD IS A LIE AND A FRAUD. JOE IMBRIANO IS THE FULLERTON INFORMER AND BECAUSE YOU HAVE THE RIGHT TO KNOW, WE DARE TO PUSH THE ENVELOPE.
Under an Elsevier user license Open archiveThe China Brain Project covers both basic research on neural mechanisms underlying cognition and translational research for the diagnosis and intervention of brain diseases as well as for brain-inspired intelligence technology. We discuss some emerging themes, wi...
Alzheimer’s disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initia...