To do so, we tested how the value of information scales in our task with two major determinants of instrumental reward value: expected reward and reward uncertainty. Second, are these principles conserved between humans and monkeys and in the information-related signals in Pal and LHb?
U.S. pharmaceutical R&D expenditures exceed those of any other major industrial sector, than high investment sectors such as computer software and services industries. Neural disorders such as multiple sclerosis, epilepsy and Parkinson’s disease inflict great pain and suffering on patients, and every...
is likely to become at least partially possible, but won’t lead to immortality. Majorobjectionshave been raised regarding the feasibility of mind uploading. Even if we could surpass every technical obstacle and successfully copy the totality of one’s mind, emotions, ...
12,13. These taxonomies generally agree on three major types of brain myeloid lineage cells: monocytes, central nervous system (CNS)-associated macrophages (CAMs)/perivascular macrophages (PVMs) and a heterogenous group of microglia that has been...
35. Luckensmeyer GB, Keast JR: Immunohistochemical characteri- sation of viscerofugal neurons projecting to the inferior mesenteric and major pelvic ganglia in the male rat. J Auton Nerv Syst 1996, 61:6-16. 36. Kepper ME, Keast JR: Specific targeting of ganglion cell sprouts provides an...
The ability to directly interfere with disease pro- gression would constitute a major improvement to cur- rent symptomatic treatments of PD. Preventive/protective medication would be more efficacious when applied early. In the DJ-1A fly model, treatment was offered as early as the beginning of ...
For H3K27me3 peaks, we identified two major clusters. One contained more promoter peaks and showed co-enrichment for H3K4me3 (cluster 5, previously referred to as ‘bivalent’). This cluster of peaks was enriched for general developmental processes. Cluster 6 contained distal H3K27me3 enriched...
Maes M and Metlzer HY The serotonin hypothesis of major de- pression. In: Psychopharmacology: the fourth generation of progress (Ed- ited by: Bloom FE, Kupfer DJ) New-York, Raven Press 1995, 933-944 53. Papolos DF, Yu YM, Rosenbaum E and Lachman HM Modulation of learned helplessness ...
APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol. Psychiatry 16, 903–907 (2011). CAS PubMed PubMed Central Google Scholar Bellenguez, C. et al. New insights on the genetic etiology of Alzheimer’s and related dementia. medRxiv 17, 10 (2020). Google ...
One major aim of current neuroscience research, then, is to study how this wiring works and what happens when it's damaged. New developments in brain scanning allow researchers to see more detailed images and determine not only where there may be damage but also how that damage affects, for...