The brain’s complex biochemical environment relies on tightly regulated interactions between neurotransmitters such as dopamine, serotonin, glutamate, and gamma-aminobutyric acid (GABA), each playing a critical role in synaptic transmission and signal modulation. These chemical messengers enable neurons to...
We therefore reasoned that membership in modO, which was predicated to have an ipsilateral recurrent connection with another member of modO, selected for glutamatergic VPNI cells and selected against GABAergic VPNI cells (which were retained in the ‘periphery’). Consistent with this, the VPNI ...
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABAAR) modulator, reduction alters neurodevelopment in a sex-linked manner. A new conditional mouse model...
Lee PG, Koo PH: Rat alpha(2)-macroglobulin inhibits NGF- promoted neurite outgrowth, TrK phosphorylation, and gene expression of pheochromocytoma PC12 cells. J Neurosci Res 1999, 57:872-883 131. Koo PH, Liebl DJ: Inhibition of nerve growth factor-stimulated neurite outgrowth by methylamine-...
Also, there are some genes related to transmitter substances and their signaling; gamma-aminobutyric acid (GABA-A) recep- tor, subunit beta 1 (Gabrb1)and guanine nucleotide binding protein, alpha o (Gnao1), which is involved in dopamine Page 7 of 13 (page number not for citation purposes)...
In a study, designers used an in vitro model to show that neurons that are subjected to GABA-containing liposomes for a period of 24 h undergo two significant alterations at the molecular level. First, there has been a considerable rise in the number of GABAA receptors (by 50%). A signif...
Its transient course, however, does not support the idea that modulations in GABAergic transmission are at the basis of the well-known DCN-based functional benefit of Lurcher mice present throughout their life. Background Inhibitory projections are sometimes placed at decisive locations within the ...
They were then incubated one night at 4°C in blocking solution with primary anti- bodies directed against mPER2 (1:250, rabbit polyclonal Page 8 of 13 (page number not for citation purposes) BMC Neuroscience 2009, 10:30 http://www.biomedcentral.com/1471-2202/10/30 IgG, at, Alpha ...
Keywords: Parkinson’s disease, alpha-synuclein, mouse models, sensorimotor function, neurodegeneration, Atp13a2, cognitive function Webpage Cristina Ghiani, University of California, Los Angeles Keywords: neural cell development, oligodendrocyte development, glia cell biology, neurodevelopmental disorders, (...
central nervous system CN: cranial nerves CSF1: colony-stimulating factor 1 DCs: dendritic cells DKK1: dickkopf-1 EMT: epithelial-mesenchymal transition EVs: extracellular vesicles GABA: gamma-amino butyric acid GAL: galanin GALR: galanin receptor...