Muscle weakness and atrophy.Damage to your peripheral nerves can weaken and shrink the muscles that are connected to them. This most commonly happens in your hands, lower legs, and feet. Such damage can weaken your grip, make you less stable on your feet, or make it difficult or even impo...
A method for detecting neuropathy and predicting foot ulcer development in human beings with health conditions like diabetes mellitus, by providing a an arrangement for recording the image of the feet of patient comprising a transparent mounting stand (2), a camera (3) connected to computer (5)...
On March 17, 2022, a 62-year‐old woman was admitted to our neurology unit with a 15- day history of progressive numbness accompanied with weakness in all four extremities. Fifteen days before admission, she experienced numbness in both hands and feet. Three days later, she felt painful in...
“owl eyes”) may be seen on axial images; pencil-like enhancement of the anterior spinal cord on sagittal views is also suggestive (Zalewski et al., 2019) (Fig. 15.17). Importantly, MRI can be normal at presentation in nearly a quarter of cases; therefore, if there is a high index...
TRPV4-RhoA binding occurs via the TRPV4 N-terminal domain, resulting in suppression of TRPV4 channel activity, inhibition of RhoA activation, and extension of neurites in vitro. Neuropathy but not skeletal dysplasia mutations disrupt TRPV4-RhoA binding and cytoskeletal outgrowth. However, inhibition...
Paclitaxel-induced peripheral neuropathy is a progressive and refractory adverse consequence of chemotherapy, which is characterized by chronic pain, a burning sensation, and tingling in the feet and hands in a “glove and stocking” distribution [5]. Neuropathic pain induced by paclitaxel often seriou...
The positioning of the feet in relation to each other was accurately noted for each condition in order to guarantee reproducibility in the subsequent trials. COP data were collected with a sample rate of 100 Hz and further processed in MATLAB (Version 2018a; MathWorks, Inc; Natick, MA) using...
CIPN-specific symptoms commonly manifest in feet and hands in typical sock and/or glove-like pattern. They may cause adjustments of therapy as well as subsequent reduction in treatment efficacy [11]. The pathophysiology of CIPN upon administration of anticancer therapies has been analyzed in detail...
The total possible score is 8 points for both feet. DPN was diagnosed when the MNSI-PE score was ≥ 2.5, based on prior studies34,35. A 10-g monofilament test was considered abnormal when an individual had a sensation of fewer than seven points on one of the two feet36. Abnormal...
Similarly, nerve conduction studies may demonstrate carpal tunnel syndrome in those presenting with greater symptomatology in the hands compared to the feet. Asymmetrical lower limb symptoms or signs may be a feature of (superimposed) lumbar radiculopathy (often accompanied ...