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Knowing one’s own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to the brain are well positioned to pr
This cleavage produces ‘detyrosinated’ tubulin (previously called Glu-tubulin), which exposes a C-terminal Glu to which a Tyr can be re-added by the tubulin tyrosine ligase (TTL; Fig. 2). TCP and TTL enzymes are ubiquitous, and their activities are spatially and temporally regulated in ...
To search for anxiolytic NPY neurons, we adopted an acute novelty stress paradigm20, in which group-housed mice were individually transferred into new empty cages without padding materials (Fig.1a) for 24 hs. Novelty stress significantly suppressed feeding in the first 4 hs (Fig.1b), foll...
are not a consequence of heightened locomotion (Supplementary Fig.2h). Altogether, LSd astrocytes selectively responded to a subset of dangerous, frightening, and stressful stimuli. They remained unresponsive to neutral and rewarding stimuli, as well as during the appetitive phase of social interaction...
interaction of the motility regulators, lis1 and dcx, with astrotactin, which was found to mediate neuron movement along the glial fiber [ 19 ]. we are not, however, aware of any experimental findings that support or refute this assumption. our model incorporates only a subset of the rich ...
Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of ciliary signaling can lead to
depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normal...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
are biologically inspired computer programs, designed to simulate the way in which the human brain processes information. ANN gather their knowledge by detecting the patterns and relationships in data (segmentation), and learn (or are trained) through experience, not by programming33,34,35,36. ANN...