Neurons of the brain and spinal cord also express their distinct and characteristic isoforms of laminin compared to the glial cells of the same CNS regions. These results suggest that, in addition to the known laminins, several novel isoforms may exist in the human embryonic CNS. The observed ...
While glia are often thought of as the supporting cast of the nervous system, the number of glial cells in the brain actually outnumbers the number of neurons by a factor of ten. Neurons would be unable to function without the vital roles that are fulfilled by these glial cells. Glia guid...
In the CNS, white matter is primarily composed of axonal bundles ensheathed with myelin, which enhance the velocity of propagation of nerve impulses in the brain. Oligodendrocyte precursor cells (OPCs) are immature and abundant reservoir cells that become myelin-forming ones after their differentiatio...
The role of TRPM2 channels in neurons, glial cells and the blood-brain barrier in cerebral ischemia and hypoxia Abstract Stroke is one of the major causes of mortality and morbidity worldwide, yet novel therapeutic treatments for this condition are lacking. This review focuses on the roles of ...
Viviani B (2006) Preparation and coculture of neurons and glial cells. Curr Protoc Cell Biol Chap. 2:Unit 2.7. doi: 10.1002/ 0471143030.cb0207s32Viviani B. 2006. Preparation and coculture of neurons and glial cells. Current Protocols in Cell Biology Chapter 2: 7. DOI: https://doi.org/...
Here, we highlight the complex molecular signaling that takes place in neurons, glial cells and the blood-brain barrier following ischemic insult. We also describe the evidence of TRPM2 involvement in these processes, as shown from numerous in vitro and in vivo studies that utilize genetic and ...
In the brain, the 5α-reductase converting testosterone (T) is present both in neurons and in glial cells, even if it prevails in neurons; the 3α-hydroxysteroid-dehydrogenase (3α-HSD), the enzyme converting dihydrotestosterone (DHT) into 3α-diol, is particularly concentrated in type 1 ast...
Glia, or glial cells, contribute to brain function mainly by insulating, supporting, and nourishing neighboring neurons. If the brain were a chocolate chip cookie and the neurons were chocolate chips, the glia would be the cookie dough that fills all the other space and suspends the chips in ...
Active brain cells produce more “maintenance” substances'. The Nerve Growth Factor (NGF) is a protein that is produced in your body in the target cells. This protein binds the neurons, marking them as active, differentiated, and responsive. The more often you challenge, exercise, and active...
Radial glial cells, ubiquitous throughout the developing CNS, guide radially migrating neurons and are the precursors of astrocytes. Recent evidence indicates that radial glial cells also generate neurons in the developing cerebral cortex. Here we invest