In addition to enteric glial cells, a recent study shows that enteric neurons expressing the neuropeptide vasoactive intestinal peptide (VIP) project nerves into the lamina propria in close proximity to ILC3s, which express the VIP receptor VIPR2 (Fig.3e).32Food consumption stimulates neuronal prod...
Neuroscience is at the stage biology was at before Darwin. It has a myriad of detailed observations but no single theory explaining the connections between all of those observations. We do not even know if such a brain theory should be at the molecular level or at the level of brain regions...
Biology and Pathology of Astrocyte-Neuron Interactions Leif Hertz Part of the book series:Altschul Symposia Series((ALSS,volume 2)) 110Accesses Abstract Metabolic interactions between neurons and glial cells can occur in at least two different ways, 1) transfer of a metabolite from a cell type, ...
Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to analyse subtyp
Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular developmentJennifer A Thompson, Andreas Zembrzycki, Ahmed Mansouri & Mel Ziman BMC Developmental Biology volume 8, Article number: 62 (2008...
Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the h... Hodges,A - 《Human Molecular Genetics》 被引量: 839发表: 2006年 Alzheimer's disease is associated with reduced expression of energy ...
Pathway analyses of multiple datasets implicated transforming growth factor β (TGF-β)/SMAD signaling in SORL1 biology, and stimulation and inhibition of this pathway modulated APOE RNA and protein levels. We further interrogated the relationship between APOE, CLU, and SORL1 in a set of 50 iPSC...
During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintain responsiveness to both small and large synaptic inputs? We demonstrate that in response to changes in activity, ...
1b), a cell-permeable fluorophore that is widely used in live-cell and super-resolution microscopy studies33. Widefield microscopy revealed that the NFLTAG mutants varied in their expression level and labeling efficiency when cells were co-transfected with the NESPylRS/tRNAPyl plasmid in the ...
The activity of RMTg GABAergic neurons increased to a high discharge level at the termination of REM sleep. RMTg GABAergic neurons directly converted REM sleep to wakefulness and NREM sleep via inhibitory projections to the laterodorsal tegmentum (LDT) and lateral hypothalamus (LH), respectively....