Neuroscience is at the stage biology was at before Darwin. It has a myriad of detailed observations but no single theory explaining the connections between all of those observations. We do not even know if such a brain theory should be at the molecular level or at the level of brain regions...
Microbes likely play a role in neuronal modulation of T cell function. When Th17-inducing or Treg-inducing bacteria are infused into a microfabricated intestine culture system, these bacteria elicit differential effects on enteric neuron gene expression.90The frequency of RORgt+Treg cells negatively co...
The emergence of molecular biology ('practising biochemistry without a licence') introduced information in place of energy as an organizing cellular principle, but in doing so forgot dynamics. For Crick's Central Dogma, information -- signals -- flowed in one direction only. Now, proteomics is ...
form a molecular program that mediates the migration process. results the model simulated the dynamic migration process, consistent with in-vivo observations of morphological, cellular and population-level phenomena. specifically, the model reproduced migration phases, cellular dynamics and population distribu...
In mammalian brain, physiological signals carried by cyclic AMP (cAMP) seem to be targeted to effector sites via the tethering of cAMP-dependent protein ki... S B,Glantz,J A,... - 《Molecular Biology of the Cell》 被引量: 207发表: 1992年 加载更多来源...
To understand the functional consequences of mixtures of oscillations at the single cell level, we recorded the spike trains from single rat cortical neurons in vitro in response to two mixed sine wave currents. The reliability of spike timing was measured as a function of the relative power, ...
- 《Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology》 被引量: 62发表: 2008年 巴西整治地方政府债务危机的经验教训及启示 20世纪80年代以来,巴西先后经历了三次大规模的债务危机,严重影响了该国的经济发展进程.为从根本上防止重蹈覆辙,巴西中央政府1998年起果断...
Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular developmentJennifer A Thompson, Andreas Zembrzycki, Ahmed Mansouri & Mel Ziman BMC Developmental Biology volume 8, Article number: 62 (2008...
The activity of RMTg GABAergic neurons increased to a high discharge level at the termination of REM sleep. RMTg GABAergic neurons directly converted REM sleep to wakefulness and NREM sleep via inhibitory projections to the laterodorsal tegmentum (LDT) and lateral hypothalamus (LH), respectively....
(Fig.1eand Supplementary Fig.6a), as expected18,19. Different intensities enhanced the firing rate of RS neurons in a level-dependent manner consistent with previous studies (Supplementary Fig.6a–c). Counter-intuitively, but consistent with the previous study in ref.19, NS units also ...