In support, neuronal nuclear factor, nuclear factor-kB was also shown to regulate neuroinflammation25. Moreover, we reported several pivotal immunosuppressive properties of neurons, in which neurons interact with autoreactive regulatory FoxP3 þ Treg via Tenc cells production and convert them to of ...
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To corroborate previous reports about non-nuclear FOXG1 localization, first, we profiled murine, E16.5 + DIV8 neocortical neurons (Fig.1A) for subcellular distribution of anti-FOXG1 immunoreactivity. In addition to the nucleus, we found FOXG1 in TUBB3+soma and neurites (Fig.1A, a,...
The sections were further incubated overnight at 4 °C with primary antibodies: rabbit anti-ionized calcium binding adaptor molecule 1 (Iba-1) to detect microglia; mouse anti-glial fibrillary acidic protein (GFAP) for detection of astrocytes; mouse anti-neuronal nuclear antigen (NeuN) to ...
Intracellular and nuclear labeling and data collection and analysis were performed as previously described [24]. Antibodies used: Trustain FcX™ (Biolegend #422301, 1:1000), Sox2 (Millipore #FCMAB112, 1:50), DCX (BD Pharmigen #561505, 1:50), and βIII tubulin (R&D Systems #IC1195C,...
we characterized changes in the subcellular localization of HSP mRNAs in primary hippocampal and spinal cord motor neurons subjected to different proteotoxic insults. Fused in sarcoma (FUS) and heterogenous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), both implicated in amyotrophic lateral sclerosis (ALS...
Nuclear factor-κB NLR: Nod-like receptor P1: Post-natal day 1 PAMP: Pathogen-associated molecular pattern PFA: Paraformaldehyde PMN: Polymorphonuclear neutrophil SEM: Standard error of the mean TEA: Triethanolamine TLR: Toll-like receptor TNF: Tumor necrosis factor.References...
0.5 μg of a nuclear hashing antibody (10 µg/ml) was added to each sample and incubated for 30 min at 4 °C. Nuclei were washed three times and finally counted using a Countess Automated Cell Counter (ThermoFisher). Three pools of nuclei were generated each containing 40,...
6c, d): tumor protein p53-induced nuclear protein 1 (Trp53inp1) which mediates cell cycle arrest or autophagy41 and its upregulation leads to the development of age-related cataracts42, and Pleckstrin homology-like domain family A, member 3 (Phlda3) which competitively suppresses Akt and ...