Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease 神经元FAM171A2介导α-突触核蛋白原纤维摄取并驱动帕金森病 网址 http://dx.doi.org/10.1126/science.adp3645 DOI 10.1126/science.adp3645doi 求助人 DQ在 2025-02-21 08:21:12 发布自法国,悬赏10积分 ...
7D)12,91. Among the top DE markers of N20 iNeurons, 10 genes were filtered as unique iNeuron markers and chosen for mutagenesis (hdac10, mthfd1l, si:ch211-153j24.3, fhdc5, shootin3, syt11b, fam171b, chrnb2b, fblim1, vamp4) (Fig. S7D). atf3 was selected as a positive ...
98 We note in this connection that Ddx1, Rtcb and Fam98A were also detected in nRNAgs in our proteomic analysis. Together, the identification of cytoskeletal components and regulatory proteins like Rtraf in our nRNAg preparation as well as the physical association of the granules with ...
The cells exhibited augmented intracel- lular calcium responses to AMPA and kainate that were mediated through calcium-permeable AMPARs lack- ing the GLUA2 subunit, which is encoded by GRIA2. The authors discuss that this could be due to a scenario where the loss of the RNA-binding protein ...
Fambrough The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c DNA Cell Biol., 14 (1995), pp. 863-867 CrossrefView in ScopusGoogle Scholar Grubman et al....
ARTICLE Received 22 Jan 2014 | Accepted 18 Jun 2014 | Published 18 Jul 2014 DOI: 10.1038/ncomms5450 Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction Satomi Ito1,*,w, Adriana Magalska2,*, Manuel Alcaraz-Iborra1, Jose P...
FAM19A5: chemokine-like protein TAFA-5; FC: fold change; FSTL1: follistatin like 1; GAD: glutamate decarboxylase; HC: healthy controls; HSP90AA1: heat shock protein 90 alpha family class A member 1; IFT122: intraflagellar transport 122; IGHG4: immunoglobulin heavy constant gamma 4; ITS...
(D) Fluorescence polarization assays using GST-RBM45 and A or m6A FAM-labeled RNA shows preferential binding to m6A RNA (Kd m6A = 462 ± 73 nM; Kd A = 1,371 ± 212 nM). Mean ± SD plotted for 3 biological replicates. (E) Schematic of RBM45 variants used for RNA pulldown assays...