All requests for raw and analyzed data and materials are promptly reviewed by the University of California San Diego (Material Transfer office) to verify whether the request is subject to any intellectual property or confidentiality obligations. Any data and materials that can be shared will be rele...
Hereditary spastic paraparesis: the real-world experience from a Neurogenetics outpatient clinic. Eur J Med Genet. 2022;653. https://doi.org/10.1016/j.ejmg.2022.104430. Méreaux JL, Banneau G, Papin M, Coarelli G, Valter R, et al. Clinical and genetic spectra of 1550 index patients with...
Statistical analyses were done using the graphpad prism 7.0 (San Diego, CA, USA). An alpha level of P < 0.05 was set for significance. Groups were compared using a one-way or two-way ANOVA followed by a Bonferroni post hoc analysis. In the case of only two groups, Student’s t-test...
Delaying oocyte manipulation is common in many researches, animal reproductive technologies and clinic assisted reproduction technologies (ART). In mammals, it is very important and necessary to study mechanisms underlying oocyte aging, which will have advantages to control oocyte aging and provide more ...
now entered Phase III trials for the therapeutic treatment of ALS.38 Interestingly, the FDA-approved drug amiloride, albeit a less lipophilic ASIC inhibitor, may also be worthy of further investigation for the treatment of ALS on the premise that it would provide a quicker route to the clinic....
ALS Unit, Hospital San Rafael, Madrid, Spain Jesus S. Mora Pardina Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain Abdelilah Assialioui & Monica Povedano MND Clinic, Neurology Department, Hospit...
However, the therapeutic potential of hADSC-derived motor neuronal cells has yet to be established in a clinic relevant SCI model. This study for the first time optimized a stepwise protocol for high efficient ADSC-motoneuron trans-differentiation and further investigated the therapeutic potential of...
antibody (1 : 1000) from Covance; CD68 rabbit polyclonal antibody (1 : 1000) from Santa Cruz Biotechnology; P2X7r rabbit polyclonal antibody (1 : 500) from Alomone Labs (Jerusalem, Israel); and GAPDH mouse monoclonal antibody (1 : 10000) from Calbiochem (San Diego, CA,...
MUNE can be applied longitudinally to understand disease course and to test protective or regenerative effects of therapeutic interventions, both in the clinic and in preclinical studies. Despite the powerful nature of repeated MUNE measures and the clinical applicability of the technique to MU pools ...
Statistical analysis was performed using GraphPad Prism v.9.3.1.471 https://www.graphpad.com (accessed on 2 December 2021) (San Diego, CA, USA). Data were expressed as box and whisker plots with Tukey’s method. We performed Kruskal–Wallis non-parametric ANOVA. Difference was considered to ...