Neuromuscular junction biologydoi:10.1016/S0022-510X(02)80066-1esJournal of the Neurological Sciences
preserving muscle size, function, and neuromuscular junction (NMJ) integrity. Interestingly, responsiveness to rapamycin differs between muscles, suggesting that the primary drivers of age-related muscle loss may differ between muscles. To dissect the key signaling nodes associated with...
(A) Entire frog neuromuscular junction (NMJ,left) and longitudinal section through a portion of the nerve terminal (right).Arrowsindicate planes of cleavage during freeze-fracture. (B) Three-dimensional view of presynaptic and postsynaptic membranes with active zones and immediately adjacent rows of ...
Defects at the neuromuscular junction (NMJ) are among the earliest hallmarks of amyotrophic lateral sclerosis (ALS). According to the “dying-back” hypothesis, NMJ disruption not only precedes but also triggers the subsequent degeneration of motoneurons in both sporadic (sALS) and familial (fALS)...
Ultrastructural study on the morphogenesis of the neuromuscular junction in the skeletal muscle of the chick The morphogenesis of the neuromuscular junction was examined at the ultrastructural level in the skeletal muscle of the lower limb of the chick. The fine s... H Hlrano - 《Zeitschrift Für...
We have examined the embryonic development of an identified neuromuscular junction (NMJ) of Drosophila melanogaster using whole-cell patch-clamp and a vari... KS Broadie,M Bate - 《Journal of Neuroscience》 被引量: 518发表: 1993年 Precision and plasticity during Drosophila neuromuscular development...
Within Tpi1E105D/null mice in the present study, alterations in structure and/or function have been evaluated at three different levels: the brain, the neuromuscular junction, and muscle. Behavioral analyses have been conducted to reveal the high-level functionality of mice modeling TPI Df. ...
Neuromuscular diseases comprise a spectrum of disorders affecting motor neurons in the spinal cord, sensory neurons in the dorsal root ganglia, peripheral nerves, neuromuscular junction and/or skeletal muscles. Cranial nerves (and their nuclei) as well as components of the vegetative system can be al...
Throughout infancy, the neuromuscular junction matures physically and biochemically, the contractile properties of skeletal muscle change, and the amount of muscle in proportion to body weight increases; as a result, the neuromuscular junction is variably sensitive to relaxants. In addition, there are ...
Terminal Schwann cells (tSCs) are a specialized group of non-myelinating SCs that cap the axon terminal of α-motor neurons at the neuromuscular junction (NMJ)4,5. There is growing evidence that tSCs are affected in peripheral neuropathies, with some disease states resulting in tSC loss6. It...