Neuroendocrine mechanisms of development, prospects of early diagnostics and prognosis of prostate cancer are analyzedP.V. GlybochkoV.M. PopkovSaratov State Medical Universitysaratov journal of medical scientific research
Neuroendocrine prostate cancer (NEPC) is a highly lethal variant of castration-resistant prostate cancer (CRPC) with poor survival rates. Current treatment options for NEPC are limited to highly toxic platinum drugs highlighting the urgent need for new therapies. This study aimed to develop a novel...
Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach Prostate cancer is highly sensitive to hormone the Cerasuolo,Marianna,Mazzarella,... - 《Cancer Research the Official Organ of the American Association for Cancer Research Inc》 被引量: 10发表: 2015年 SNAI2/Slug...
Prostate Centre. Prostate cancer specimens were obtained from patients following a protocol approved by the Clinical Research Ethics Board of the University of British Columbia and the BC Cancer Agency (all patients signed a consent form approved by the Ethics Board). For TMA #2, benign prostate ...
Research/Regulatory Issues in Drug Development in the US - Part II Cristian I.SurcelM.D., Ph.D., ...Members of the Prostate Cancer Working Group of the Young Academic Urologists Working Party of the European Association of Urology, inUrologic Oncology: Seminars and Original Investigations, 201...
Hormonal therapy is an important treatment for advanced/metastatic prostate cancer. But it can induce neuroen-docrine(NE) differentiation in prostate cancer cells. These NE cells will secrete manifold neural peptide or hormones which can lead to androgen-independent growth of non-NE tumor cells. Wh...
Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activation is broadly used and continually improved. However, a subset of patients eventually progresses...
Molecular mechanisms of neuroendocrine differentiation in prostate cancer progression Journal of Cancer Research and Clinical Oncology - Rapid evolution of the therapeutic management of prostate cancer, especially in in second-generation and... Y Xie,S Ning,J Hu - 《Journal of Cancer Research & ...
Neuroendocrine (NE) differentiation in tumors of the prostate or in the setting of prostate cancer (PCa) is rare. A survey of these lesions is presented, including usual PCa with focal NE marker-positive cells, Paneth cell-like change, prostatic ‘carcinoid’, high-grade NE carcinoma, as well...
MicroRNA determinants of neuroendocrine differentiation in metastatic castration-resistant prostate cancer Article 09 October 2020 Introduction Neuroendocrine carcinomas (NECs) are high-grade tumors that can arise in the lung, colon, prostate, or bladder among other anatomic sites. NECs are characterized...