The function of NE cells in PCa remains poorly understood, and one important characteristic of these cells is their lack of expression of AR and resistance to hormonal therapy. In addition, many patients develop the more aggressive small-cell neuroendocrine carcinoma (SCNC) after hormonal therapy....
Neuroendocrine cells in prostate cancer.: Neuroendocrine (NE) cells are found in prostate tumors, and their incidence is considered a promising prognostic indic
Neuroendocrine (NE) cells are found in prostate tumors, and their incidence is considered a promising prognostic indicator for the development of androgen-independent disease. NE cells are derived from non-NE prostate cancer cells and secrete factors that can act in a paracrine manner to stimulate ...
Neuroendocrine (NE) differentiation in tumors of the prostate or in the setting of prostate cancer (PCa) is rare. A survey of these lesions is presented, including usual PCa with focal NE marker-positive cells, Paneth cell-like change, prostatic ‘carcinoid’, high-grade NE carcinoma, as well...
Neuroendocrine cells in tumour growth of the prostate. Endocr Relat Cancer. 1999; 6 (4):503–519.Abrahamsson PA. Neuroendocrine cells in tumour growth ... Abrahamsson,P. - 《Endocr Relat Cancer》 被引量: 518发表: 1999年 Neuroendocrine expression in metastatic prostate cancer: evaluation of hi...
(EMT), whereas KIF1A overexpression promoted these processes. Targeting KIF1A inhibited the growth of NE differentiated prostate cancer (PCa) cells in vitro and in vivo. Mechanistically, KIF1A bound with O-linked N-acetylglucosamine transferase (OGT) and regulated its protein expression and activity...
(proliferation of neighboring cancer cells in a paracrine manner by secretion of neuroendocrine products).Neuroendocrine prostate cancer is an aggressive variant of prostate cancer that commonly arises in later stages of castration resistant prostate cancer.The detection of neuroendocrine prostate cancer has...
Introduction and Objective Neuroendocrine cells in the prostate are closely associated with the development of hormone-refractory prostate cancer (HRPC) and display higher sensitivity to the platinum derivatives. We hypothesize that prot... Y Mitsui,N Arichi,M Hiraki,... - 《Urology》 被引量: 0...
Hormonal therapy is an important treatment for advanced/metastatic prostate cancer. But it can induce neuroen-docrine(NE) differentiation in prostate cancer cells. These NE cells will secrete manifold neural peptide or hormones which can lead to androgen-independent growth of non-NE tumor cells. Wh...
Introduction and Objective Neuroendocrine cells in the prostate are closely associated with the development of hormone-refractory prostate cancer (HRPC) and display higher sensitivity to the platinum derivatives. We hypothesize that prot... Y Mitsui,N Arichi,M Hiraki,... - 《Urology》 被引量: 0...