Our recent findings showed that a microbial toxin can specifically target the ileal-associated microbiota that regulate Th17 immunity, leading to multiple downstream pathological effects compatible with body-first PD. This toxin also targets neuronal mitochondria inducing its dysfunction, which is also ...
Student’s t-test was used to determine the significance of differences (p < 0.05) between the two groups. One-way analysis of variance with post-hoc Tukey’s multiple comparison tests was used to compare multiple groups. Values are presented as mean ± SEM (standard error of the ...
Student’s t-test was used to determine the significance of differences (p < 0.05) between the two groups. One-way analysis of variance with post-hoc Tukey’s multiple comparison tests was used to compare multiple groups. Values are presented as mean ± SEM (standard error of the ...
Boosting NAD+ synthesis by administration of NAD+ precursors is also beneficial in models of neurodegenerative diseases (for example of AD (Sorrentino et al., 2017)) and encouraged the initiation of multiple clinical trials (Lautrup et al., 2019), including one on the NAD+ precursor niacin (...
(Aβ) deposits and dying cells but can also lead to worsening of the pathology when these cells are abnormally activated. It is well established that microglia, the principal immunocompetent mediators in the brain, can display multiple reactive phenotypes that may differ with the stage and ...
The number of maximum spontaneous alternation behavior was then the total number of arms entered minus two and percent spontaneous alternation was calculated as (actual alternations/maximum alternations) × 100. The maze was cleaned with a 10% ethanol solution and dried with a cloth before the next...
The coordinates relative to bregma were, anteroposterior: −6.30 mm, −7.80 mm; lateral, ±1.50 mm; dorsoventral, −1.50 mm (minus indicates a position posterior to bregma). Correlative light and electron microscopy (CLEM) For the merging of confocal fluorescence microscopy ...
Thus, development of inhibitors, such as HV-3-like reagents, may have the potential to open up a new therapeutic route for HD and multiple polyglutamine diseases in which VCP translocation to mitochondria is characterized. Methods Antibodies and reagents. Protein phosphatase inhibitor and protease ...
N6-methyladenosine (m6A) modification of RNA influences fundamental aspects of RNA metabolism and m6A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m6A modification in the pathogenesis of Alzh
which may advance our understanding of the inherent relationship between the two diseases. Although people infected with SARS-CoV-2 frequently display neurological symptoms, multiple manifestations remain unrecognized. First, neurological symptomatology is not always present, and neurological symptoms are often...