富集到的通路主要涉及神经活性配体-受体相互作用(neuroactive ligand-receptorinteraction)、环腺苷酸信号通路(cAMPsignaling pathway)、磷脂酰肌醇3-激酶-蛋白激酶通路(PI3K-Akt signaling pathway)等,表明34个核心靶点可能是主要通过调节这些通路来起到治疗或干预疾病的作用。 2.7.4成分-靶点-通路网络构建 根据筛选得到的Z...
根据P值大小,排名前5的通路包括神经活性配体受体相互作用(neuroactive ligand-receptor interaction)、5-羟色胺能突触(serotonergic synapse)、钙信号通路(calcium signaling pathway)、cAMP信号通路(cAMP signaling pathway)及肿瘤坏死因子信号通路(TNF signaling pathway)。 3.5“养血清脑丸–组方中药–活性成分–偏头痛–...
the neuroactive ligand–receptor interaction pathway.Background: The potential mechanism underlying the association between Homologous recombination deficiency (HRD) and immunotherapy in colon cancer has not been investigated.Methods: The exon sequencing data and transcriptome data of 456 colon adenocarcinoma ...
KEGG PATHWAY_ Neuroactive ligand-receptor interaction - Rattus norvegicus (rat)-TRPV1 [ Pathway menu
1.1 Drug Targets 药物靶点 Drug targets是蛋白质 蛋白质是大型生物分子,由很多的氨基酸amino acids组成 蛋白质结构的要素有螺旋(helic),折叠sheet和无规则卷曲loop 可以把蛋白质想象成一个大型的球状结构,上面有很多的凹槽(grooves)什么是结合部位(Binding Site)?
Adkins DE, Khachane AN, McClay JL, et al. SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treat- ment response: data from the CATIE study. Schizophr Res. 2012;135:200-201....
Adkins DE, Khachane AN, McClay JL, et al. SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treat- ment response: data from the CATIE study. Schizophr Res. 2012;135:200-201....
Genes in neuroactive ligand-receptor interaction pathways.Chuanwang CaoZhiying WangChangying NiuNicolas DesneuxXiwu Gao
Validation analysis for targets in neuroactive ligand-receptor interaction pathway.Yan, KongXijun, LiangLin, LiuDongdong, ZhangChao, WanZhenji, GanLiudi, Yuan
The neuroactive steroid 3 α -hydroxy-5 β -pregnan-20-one is a two-component modulator of ligand binding to the GABA A receptor. Eur J Pharmacol. 1994; 269 :157–163.Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW (1994b) The neuroactive steroid 3α-hydroxy-5...