Neuregulin1 is an epidermal growth factor (EGF)-like domain-containing protein that has multiple isoforms and functions as a local mediator in the control of various cellular functions. Here we show that type I isoform of neuregulin1 with an α-type EGF-like domain (Nrg1α) is the major is...
Finding a druggable target for schizophrenia: Fig. 1. The article focuses on a study to determine the mechanism of neuregulin-1 (NRGl) or its receptor ERBB4 signaling in schizophrenia and design strategies for... Beatriz,Rico - 《Proceedings of the National Academy of Sciences》 被引量: 0发...
Thus, regulation of their expression by sex steroids may be a general mechanism by which sex steroids exert their effect on pain sensitivity. One such mechanism, the progesterone specific regulation of the growth factor, neuregulin-1, following nerve root injury in the rat, is described in ...
A visual representation of Neuregulin 1's main molecular pathways, associated with a discussion about their importance to schizophrenia research; 2. A new heatmap of Neuregulin 1 and its receptor's expression in brain tissues most relevant to the understanding of schizophrenia, created after the ...
Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Requ... .Protein-trap insertional mutagenesis uncovers new genes involved in zebrafish skin development, including a neuregulin 2a- based erbb signaling ...
Neuregulin-1 (NRG-1)/ErbB signaling has an indispensable role in cardiac development and in the maintenance of the structural and functional integrity of the human adult heart in health and disease. Several animal studies have now demonstrated the therapeutic effects of NRG-1 during acute cardiac ...
Our strategy is based on the observation that the Q43L mutant of the naturally-occurring ErbB4 agonist Neuregulin 2beta (NRG2尾) functions as a partial... RL Cullum,II David,RB Gupta - Aiche Meeting: November 被引量: 0发表: 2014年 The EGF family hormone Neuregulin2{alpha} antagonizes Erb...