ErbB3/HER3 does nothomodimerize upon neuregulin binding at the cell surface. FEBS Lett. 2004; 569 :332–336. doi: 10.1016/j.febslet.2004.06.014. [ Cross Ref ]Berger M.B., Mendrola J.M., Lemmon M.A. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface. ...
Neuregulins, members of the largest subclass of growth factors of the epidermal growth factor family, mediate a myriad of cellular functions including survival, proliferation, and differentiation in normal tissues through binding to receptor tyrosine kinases of the ErbB family. However, aberrant neuregul...
Molecular studies suggest that NRG1–EGF-like domain binding stimulates ErbB4 receptor phosphorylation, which results in activation of a set of downstream signaling cascades (e.g., PI3 kinase/AKT, ERK, and perhaps others) (reviewed in ref. 48). Several studies indicate that ErbB4 signaling in...
(blue) lacks a functional intracellular tyrosine kinase domain and exists on the cell surface in an autoinhibited conformation (resulting from the interactions between the S1 and S2 domains). Bivalent binding of NRG1 (NRG, red dumbbell) to the L1 and L2 domains of ErbB3 rearranges the ...
Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors 保存条件: 2-8℃ 说明书地址: 点击查看详细 打印此页 关闭此页 上一个:GRIP1, RBX-100UG[AB5547/EA] 下一个:BDNF, RBX (AFFFIN PUR)-20UG...
HaploReg v4 was used to annotate the SNPs for regulatory regions (promoter and enhancer histone marks, DNase I hypersensitivity, protein binding and regulatory motifs).55 In addition, SPANR56 scores for splicing disruption potential were extracted for the highlighted SNPs. Differential expression and ...
Alpha4beta2 and alpha7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision- making tasks. Neuroscience 230: 121–131. Nakauchi S, Sumikawa K (2012). Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in ...
HuR is an RNA-binding protein that binds directly to YAP, as demonstrated by the RNA immunoprecipitation method in osteosarcoma cells; the knockdown of HuR reduces the stability of RNA from YAP [54]. The small doses of Dox used in this study may reduce YAP RNA stability by decreasing HuR,...
As used herein, “epidermal growth factor-like domain” or “EGF-like domain” refers to a polypeptide fragment encoded by the neuregulin gene that binds to and activates ErbB2, ErbB3, ErbB4, or heterodimers or homodimers thereof, and structurally similar to the EGF receptor-binding domain as...
Proteomic analysis performed on heparin-binding proteins from CMBM-MSCconfirmed the presence of four unique NRG-1 peptides identified by mass spectrometry in the 40-50 kDa region. As shown in FIG. 4D, the peptides were derived from the heparin-binding Ig-like domain and the common EGF (EGFc...