Circulating tumor cells (CTCs) drive metastasis, the leading cause of death in individuals with breast cancer. Due to their low abundance in the circulation, robust CTC expansion protocols are urgently needed to effectively study disease progression and therapy responses. Here we present the ...
Hyperglycemia is a risk factor for breast cancer-related morbidity and mortality. Hyperglycemia inducesNeuregulin 1(Nrg1) overexpression in breast cancer, which subsequently promotes tumor progression. However, molecular mechanisms underlying hyperglycemia-inducedNrg1overexpression remain poorly understood. Here,...
For similar reasons, the ErbB2 monoclonal antibodies (Trastuzumab) that are used to treat Her2+ breast cancer, or the molecules (e.g., recombinant NRG1β and anti-ErbB4 antibodies) that are currently in development for heart disease and cancer might not be useful for neurodevelopmental ...
Heregulin beta-1 (Neuregulin-1, Acetylcholine Receptor-inducing Activity, Breast Cancer Cell Differentiation Factor P45, Glial Growth Factor, Heregulin, Neu Differentiation Factor, Sensory and Motor Neuron-derived Factor) (MaxLight 650) 英文别名: Heregulin beta-1 (Neuregulin-1, Acetylcholine Receptor-in...
Neu- regulins 1- 4 are expressed in the cytoplasm or nuclei of ductal car- cinoma (in situ) of the human breast. Breast Cancer Res Treat. 2006; 96:163-168.Marshall C, Blackburn E, Clark M, Humphreys S, Gullick WJ. Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ...
The single-most HKI-272-sensitive cell line was the erlotinib-refractory MDA-MB-175-VII breast cancer cell line, and does not exhibit HER2 amplification. Significantly, this cell line reportedly expresses a NRG1 fusion protein, as a consequence of a chromosomal translocation, that results in ...
An essential role for NRG-1 and ErbB in heart development and functionality has been suggested by studies in conditional NRG-1/ErbB-deficient mice and by the cardiac-related side effects of anti-ErbB2 antibody therapies used for treatment of breast cancer. In vitro and in vivo studies using ...
The clinical relevance of the NRG1 pathway was first linked to the amplification and overexpression of erbb2 in a subtype of breast tumor cells, which is indicative of highly proliferative cells with a poor prognosis following conventional chemotherapy. The development of targete...
Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein(NRG1) (Active) uniprot号: 规格: ￥620 图像: 基因名称: NRG1 别名: Pro-NRG1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin 种属: Homo sapiens (Human) 蛋白描述: Partial ...
All four forms of neuregulin are expressed in the cytoplasm or nuclei of in situ ductal carcinoma of the breast (Marshall et al., 2006). MTLn3 breast cancer cells overexpressing ErbB3 receptor display increased invasive behaviour in in vitro assays when exposed to HRG-β1 (Hernandez et al.,...