The study of brain development in humans is limited by the lack of tissue samples and suitable in vitro models. Here, we model early human neural tube development using human embryonic stem cells cultured in a microfluidic device. The approach, named microfluidic-controlled stem cell regionalization...
Previous studies showed that mutations in Tctn1 and Tctn2, two members of the tectonic family, have been reported to disrupt neural tube development in humans and mice, but the functions of Tctn3 in brain development remain elusive. In this study, Tctn3 knockout (KO) mice were generated by...
摘要: Neural tube closure in humans initiates at multiple sites : The 35th Annual Meeting of the Japanese Teratology Society NAKATSU T. , OWABE C. , YAMADA S. , SHIOTA K. Congenital anomalies 35(3), 379-380, 1995-09-30年份: 1995 ...
neural tube defectsspina bifidaNeural tube defects (NTDs) are the second most common congenital malformations in humans affecting the development of the central nervous system. Although NTD pathogenesis has not yet been fully elucidated, many risk factors, both genetic and environmental, have been ...
Ultrasound studies show that in humans the neural tube begins to form at around 21-23 days after fertilization, when the embryo is just 2–3 mm in length. The first change (which occurs at about day 18) is the appearance of the neural plate, a broad area of thickening in the dorsal...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook Dictionary Thesaurus Medical Wikipedia Related to Neural Tube:neural plate,neural tube formation neural tube [′nu̇r·əl ′tüb] (embryology) The embryonic tube that differentiates into brain and spinal cord. ...
Hence, NTDs represent one of the commonest, most severe birth defects in humans. The term NTDs reflects the origin of the malformations. In normal development, the neural plate , the precursor of the brain and spinal cord in the early embryo, undergoes folding and fusion to form the neural...
In a case-control study, we examined whether parental occupational exposures were related to neural tube defect (NTD)-affected pregnancies among Mexican Americans living along the Texas-Mexico border. Case women were 184 Mexican-American women with NTD-affected pregnancies; control women were 225 stud...
s disease and Alzheimer’s disease. However, research on organoids in early neural development has received insufficient attention, especially that focusing on neural tube precursors. In this review, we focus on the recent research progress on neural tube organoids and discuss both their challenges ...
14.However, unlike pilonidal sinus in humans, dermoid sinus in dogs is a neural tube defect. 然而,与人类的藏毛窦不同, 皮窦是因犬只的神经管缺陷引起的. 15.Folic Acid helps maintain a healthy heart and helps to prevent neural tube defects in pregnancy. ...