Are neural stem cells (NSCs) maintained as totipotent precursors by the specialized environment within the stem cell niche or are they simply progenitors, which, while retaining their ability to proliferate, are parcellated and restricted along with their postmitotic brethren? In this review, we ...
progenitors, because separate populations give rise to neurons or glial cells and they show only limited self-renewal. Classification systems to further distinguish these brain-specific populations operationally are still evolving (Seaberg and van der Kooy, 2003). Adult stem cells are difficult to ...
Embryonic stem (ES) cells acquire NSC identity with a default mechanism. Under the regulations of leukemia inhibitory factor (LIF) and fibroblast growth factors, the NSCs then become neural progenitors. Neurotrophic and differentiation factors that regulate gene expression for controlling neural cell ...
This explains why the brain is particularly sensitive to defects in cell division and requires specific proliferation control mechanisms. Drosophila melanogaster neural stem cells and mammalian cortical progenitors have emerged as the key model systems to study proliferation control in the brain. In D. ...
We found that G1 lengthening was associated with the transition from stem cell-like apical progenitors to fate-restricted basal (intermediate) progenitors. Unexpectedly, expanding apical and basal progenitors exhibit a substantially longer S-phase than apical and basal progenitors committed to neuron ...
Thy1-YFP: an effective tool for single cell tracing from neuronal progenitors to mature functionally active neurons Ante Plećaš Katarina Kapuralin Ivan Alić ResearchOpen Access22 Jan 2025Cell Death Discovery Volume: 11, P: 18 Multifactorial approach is needed to unravel the maturation phases ...
ReNcell neural progenitors are immortalized human neural stem cell lines that can differentiate into neurons, astrocytes sand oligodendrocytes. Neural Stem Cell FAQs Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation. Protocols Alzheimer’s In A Dish™...
sequencing (seq) on several human induced pluripotent stem (iPS) cells derived neural stem cell (NSC) lines and one fetal brain derived NSC line to study inherent cell type heterogeneity at proliferating neural stem cell stage and uncovered predisposed presence of neurogenic and gliogenic progenitors...
Taken together, our single-cell transcriptomic analyses reveal that the directly converted iNSCs consitute a homogenous stem cell population expressing established NSC markers and do not represent a heterogenous mixture of committed neural progenitors. Additionally, the iNSCs do not express any pluripotency...
ReNcell neural progenitors are immortalized human neural stem cell lines that can differentiate into neurons, astrocytes sand oligodendrocytes. Neural Stem Cell FAQs Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation. Protocols Alzheimer’s In A Dish™...