Network medicine integrates functionally important protein–protein interactions (PPIs), and has been used to identify critical pathways that regulate endophenotypes of relevance to HCM (e.g., fibrosis)6,7. However, prior PPI networks have not incorporated patient-level variability in pathobiology as ...
Samples were submitted to an Orbitrap Fusion mass spectrometer (Thermo Fisher Scientific) coupled to a NanoLC-2D HPLC system (Eksigent, Dublin, CA) or EASY-nLC 1000 system (Thermo Fisher Scientific, Germany). Samples were loaded onto a self-made column (75 μm × 150 mm) packed ...
8. A system comprising: at least one processor; and memory comprising instructions that, when executed by the at least one processor, cause the system to: receive a plurality of packets; process a first portion of the plurality of packets in accordance with a first rule set; responsive to ...
Study drug (mavacamten or matching placebo, which were identical in appearance) was labeled with a unique identifying number that was assigned to a patient through the interactive response system. The principal investigator, site staff, and participants were masked. Randomization was stratified by ...
Randomization and Masking An interactive response system was used to randomize patients in a 2:1 ratio to receive mavacamten or matching placebo. Randomization was stratified based on current use of β-blocker. All patients, study investigators and staff, the sponsor, clinical site monitors, and...
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reformatting the subset of information specified by the packet in accordance with a logging system standard; and routing, by the packet security gateway, the packet to a monitoring device; receiving, by the packet security gateway and after performing packet filtering on the first portion of the ...
Abstract Importance Identifying successful strategies to increase COVID-19 vaccination among skilled nursing facility (SNF) residents and staff is integral to preventing future outbreaks in a continually overwhelmed system. Objective To determine whether a multicomponent vaccine campaign would increase vaccine...
While not representative of the entire US health care system, we have no reason to believe that the trends described herein would be different at other institutions. Furthermore, the click rate estimates may be conservative because systems with robust information security programs would likely have ...