网状Meta 分析(network meta-analyses,NMA) 可以同时进行直接与间接比较,即使是相比较的两种治疗药物从未进行过直接对比,该分析方法可以将一系列不同治疗方法的随机临床试验数据汇总, 然后就给定的治疗终点进行点及可信区间估计,同时对不相关性进行评估。 此篇文章用到的数据来源于治疗进展性帕金森病药物的 Meta 分析[1...
The ability to synthesise indirect evidence and evaluate multiple interventions with a common comparator in one analysis separates NMA from conventional pairwise meta-analyses. NMA is vital for evidence-based decision-making because it allows assessment of direct as well as indirect evidence. Given its...
Two network meta-analyses (NMAs) comparing SuperPATH, the direct anterior approach (DAA), and conventional approaches showed some advantages of SuperPATH2,3. The strong limitation of those two NMAs was that they summarized all conventional approaches, although these differ significantly in terms of ...
Estimates in light brown are derived from the pairwise meta-analyses, where MD less than 0 favors the row-defining treatment of each cell. iCBT indicates internet-based cognitive behavioral therapy; TAU, treatment as usual; WL, waiting list. Figure 3. Aggregated Meta-analytic Effect Sizes for ...
The results of our meta-analysis were consistent with the results concluded from the previous study. However, acupuncture was clearly more effective than not only placebo and sham acupuncture but also alpha blockers and antibiotics. Moreover, two pair-wise meta-analyses to assess the efficacy of ...
We assessed individual studies with the Cochrane risk of bias tool23 and the certainty of evidence using the Confidence in Network Meta-Analysis framework (CINeMA).29 We evaluated possible heterogeneity of treatment effects and the robustness of our findings with subgroup network meta-analyses using ...
2.4. Statistical analyses First, this network meta-analysis was based on the Bayesian theorem using the Markov chain Monte Carlo (MCMC) method. The results were reported as pooled odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Second, we created a Bayesian random effe...
A good place to start is with the package vignettes which walk through example analyses, seevignette("vignette_overview")for an overview. The series of NICE Technical Support Documents on evidence synthesis gives a detailed introduction to network meta-analysis: ...
This network meta-analysis attempts to estimate the relative efficacy and safety of systemic therapies for advanced, treatment-naive, BRAF-mutated
2, 3, 4, 5 While direct closure represents a suboptimal method of closure, controversy exists regarding the possible benefits of the eversion technique over conventional endarterectomy; four pairwise meta-analyses pooled the results of the existing trials and although the initial impression was ...