网状Meta 分析(network meta-analyses,NMA) 可以同时进行直接与间接比较,即使是相比较的两种治疗药物从未进行过直接对比,该分析方法可以将一系列不同治疗方法的随机临床试验数据汇总, 然后就给定的治疗终点进行点及可信区间估计,同时对不相关性进行评估。 此篇文章用到的数据来源于治疗进展性帕金森病药物的 Meta 分析[1...
network meta-analyses can not only compare multiple interventions but also utilize indirect evidence which increases their precision.On top of that,they can also rank competing interventions.In this mini-review,we have aimed to elaborate on the principles and techniques governing network meta-analyses ...
Frequentist framework Bayesian framework (probabilistic interpretation of uncertainty and ranking of interventions) Step wise approach (multiple sequential meta-analyses, followed by indirect comparison of pooled pairwise results) Simultaneous evidence synthesis of all pairwise comparisons across the range of ...
meta-analyses increase the precision of the effect estimate [1]. Conventional meta-analyses, however, address only single paired comparisons and are therefore of limited use when multiple reasonable options exist. One could envision a series of conventional...
Email:ztsdoctor@126网状Meta分析(networkmeta-analyses,NMA)可以同时进行直接与间接比较,即使是相比较的两种治疗药物从未进行过直接对比,该分析方法可以将一系列不同治疗方法的随机临床试验数据汇总,然后就给定的治疗终点进行点及可信区间估计,同时对不相关性进行评估,迅速受到临床医师、指南制定者、卫生技术机构的欢迎 ...
type of studies being combined, there is even more potential for combining studies that are not adequately similar.The quality of some recent network analyses in the hypertensive literature highlights the problems of this type of analysis.(See limitations of the ALLHAT network meta-analysis-details)...
Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients BackgroundAntithrombotic therapy reduces stroke, embolism and mortality in patients with atrial fibrillation (AF); however, meta-analyses have focused on p... A Dogliotti,E Paolasso...
2.4. Statistical analyses First, this network meta-analysis was based on the Bayesian theorem using the Markov chain Monte Carlo (MCMC) method. The results were reported as pooled odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Second, we created a Bayesian random effe...
Industry commissions contracting companies to perform network meta-analysis for health technology assessment (HTA) and reimbursement submissions. Our objective was to estimate the number of network meta-analyses performed by consulting companies contracted by industry, to assess whether they were published,...
Systematic reviews and meta-analyses of randomized trials have long been important synthesis tools for guiding evidence-based medicine. More recently, network meta-analyses, an extension of traditional meta-analyses enabling the comparison of multiple interventions, use new statistical methods to incorporate...