Our algorithm, netNMF-sc, combines network-regularized non-negative matrix factorization with a specialized procedure to handle the large fraction of zero entries in the transcript count matrix. The matrix factorization results in a low-dimensional representation of the transcript count matrix, while ...
netNMF-sc: Leveraging gene-gene interactions for imputation and dimensionality reduction in single-cell expression analysis 来自 Semantic Scholar 喜欢 0 阅读量: 76 作者: Rebecca Elyanow,Bianca Dumitrascu,Barbara E Engelhardt,Benjamin J Raphael 摘要: Single-cell RNA-sequencing (scRNA-seq) enables high...