Genetics Nesprins in neuromuscular and cardiac disease THE UNIVERSITY OF CHICAGO Elizabeth M. McNally Roy-PuckelwartzMegan JaneMutations in the gene encoding the inner nuclear membrane proteins lamins A and C, produce striated muscle dysfunction known as Emery Dreifuss muscular dystrophy (EDMD). ...
nesprins基因在此分化过程中的表达 摘要 第一部分 小鼠胚胎干细胞分化为心肌细胞的体外实验 目的探索提高胚胎干细胞(embryomc stemcell,ESC)体外诱 导分化为心肌细胞的实验方法。 方法 1.制备原代小鼠胚胎成纤维细胞(mouseembryo fibroblasts,MEF) 饲养层。
Kinesin-1 can exert a point force on the nuclear envelope via association with nesprins, and loss of kinesin-1 causes failure in neuronal migration in vivo Thus, microtubules steer the nucleus and drive its rotation and translocation via a dynamic, focal interaction of nesprins with kinesin-1 ...
To further substantiate the role of Bax in the NE to cytoplasmic redistribution of nesprins, we expressed Bax in Bax/Bak DKO MEFs using a doxycycline-inducible cell line (C16 DKO MEFs). After doxycycline treatment, the C16 DKO MEFs were treated with cisplatin in the presence of Q-VD-OPH. ...
Nesprins are a family of that are primarily known for their along the . Together with SUN , they form the core of the LINC (Linker of and ) complex that traverses both to connect the and the nuclear interior. Based on their structure and interactions, Nesprins integrate the into the of...
Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells. Development 2015; 142:218-28.Wilson MH, Holzbaur ELF. Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells. Development 2015; 142(1):218-28; PMID:25516977...
Key components of the \\\{LINC\\\} complex are the nesprins (Nuclear Envelope \\\{SPectrin\\\} Repeat proteINS) that were initially described as large integral \\\{NE\\\} proteins. However, nesprin genes are complex and generate many variants, which occupy various sub-cellular compartments...
Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprinsApoptosisNucleoproteinsThe canonical function of Bcl-2 family proteins is to regulate mitochondrial membrane integrity. In response to apoptotic signals the multi-domain pro-apoptotic proteins Bax and Bak are ...
Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprinsThe canonical function of Bcl-2 family proteins is to regulate mitochondrial membrane integrity. In response to apoptotic signals the multi-domain pro-apoptotic proteins Bax and Bak are activated and ...
Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprinsdoi:10.1038/S41420-020-00327-6Liora LindenboimDan GrozkiAyelet R. Amsalem-ZafranAida Pea-BlancoGregg G. GundersenChristoph BornerDidier HodzicAna J. Garcia-Sáez...