MafG-mediated nuclear retention may enable Nrf2 proteins to evade cytosolic proteasomal degradation and consequently stabilize Nrf2 signaling. For the first time, we show that under the physiological condition, the NESzip motif can be switched-off by heterodimerization....
CadinanesTranscription factorsSemisynthesisAntiproliferative activityThe effects of ten natural cadinane sesquiterpenoids isolated from Heterotheca inuloides on the pathways of the NF-κB, Nrf2 and STAT3 transcription factors were studied for the first time. The main constituent in this species, 7-...
Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif[J]. Biochimica et Biophysica Acta, 2008,1783:1847-1856.Li W, Yu S, Liu T et al (2008) Heterodimerization with small Maf pro- teins enhances nuclear retention of Nrf2 via masking the ...