This 97 kDa cell surface-associated enzyme functions in the periphery and central nervous system, where it has been shown to degrade small peptides that are involved in processes such as blood pressure regulation and nociception [108]. The crystal structure of its ectodomain (residues 55–750) ...
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes Endocrinol. 2018;6:464–75. Article PubMed PubMed Central Google Scholar Januzzi JL Jr., Prescott MF, Butler J, Felker GM...
These exhibit a 90% reduction in brain Aogen levels and low blood pressure that is maintained during aging at 16 and 70 weeks in hypothalamus (HYPO) and medulla (MED). HYPO ACE2 mRNA was 45% higher in ASrAogen than control SD rats and higher in older ASrAogen vs. younger rats. ...
Natriuretic peptides such as B-type natriuretic peptide (BNP) are important cardioprotective hormones with essential functions in sodium excretion, water balance and blood pressure regulation. Consequently, the catabolism of these peptides is in the focus of clinical research. In previous studies, we ...
The renin-angiotensin-aldosterone system and its therapeutic targets - ScienceDirect Neprilysin inhibitorMas receptor agonistACE2The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of blood pressure and body... KMMC A,DMB B,AHJD B - 《Experimental Eye Research》 ...
Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318 healthy human subjects and in murine ob...
Neprilysin is responsible for breaking down natriuretic peptides and other vasoactive substances. Inhibiting neprilysin prevents the degradation of natriuretic peptides, enhancing their beneficial effects on blood pressure regulation. Natriuretic Peptides, including atrial natriuretic peptide (ANP) and brain ...
Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure wi... AimsThe first in class angiotensin receptor neprilysin inhibitor, LCZ696 has been shown to reduce levels of N-terminal pro-brain natriuretic ...
The angiotensin receptor–neprilysin inhibitor sacubitril/valsartan has been shown to effectively reduce ambulatory 24-h blood pressure in patients with hypertension, and improvements in many aspects of hemodynamic function have also been reported. Overall hemodynamic effects on arterial stiffness and ...
Another challenge in using NEP as an anti-AD therapy is attributed to the substrate specificity of the enzyme. In addition to Aβ, NEP is capable of degrading other peptides involved in several physiological processes such as blood pressure regulation and nociception. Examples include neuropeptide ...