Lombel RM, Hodson EM, Gipson DS (2013) Treatment of steroid- resistant nephrotic syndrome in children: new guidelines from KDIGO. Pediatr Nephrol 28:409-414Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO[J] . Rebecca M. Lombel,Elisabeth M. Hodson,Debbie...
. In children, nephrotic syndrome is most commonly caused by minimal change disease ( MCD). Nephrotic syndrome can also be a manifestation of advanced renal disease in systemic conditions (e.g., diabetic nephropathy or amyloid nephropathy). Typical laboratory findings of nephrotic syndrome ...
In the past 10 years, many reports have suggested that rituximab, a chimeric anti-CD20 monoclonal antibody, is effective for children with complicated, frequently relapsing or steroid-dependent nephrotic syndrome (FRNS/SDNS). However, those reports were case reports, case series, retrospective surveys...
Secondary steroid-resistant nephrotic syndrome (SRNS) refers to the condition when patients with initial steroid-sensitive nephrotic syndrome develop steroid resistance in subsequent relapses. Long-term outcomes of secondary SRNS in children are uncertain. Methods This was a single-center retrospective stud...
IntroductionNephrotic syndrome is a disorder characterized by severe proteinuria, hypoproteinemia, and generalized edema resulting from damage to the glomerular basement membrane. In Western countries, nephrotic syndrome affects 2 of 100,000 children per year [1]. In Japan, approximately 1,300 new cas...
Steroid Sensitive Nephrotic Syndrome Chapter© 2023 References Noone DG, Iijima K, Parekh R. Idiopathic nephrotic syndrome in children. Lancet. 2018;392:61–74. ArticlePubMedGoogle Scholar Cameron JS. Five hundred years of the nephrotic syndrome: 1484–1984. Ulster Med J. 1985;54:S5–19. ...
Nephrotic syndrome (NS) is the commonest glomerular disease among children. It is characterized by heavy proteinuria and is a risk factor for hypothyroidism in the affected children. Hypothyroidism is of concern because it affects the physical and intell
The most common diseases leading to the nephrotic syndrome are: Diagnosis 1. How do the clinical features of MCD, FSGS, and MN vary? MCD may lead to a mild or benign case of nephrotic syndrome. MCD is the most common cause of nephrotic syndrome in children. Onset may be rapid, and spo...
Mostcommoncauseinchildren MembranousNephropathy(40%) Mostcommoncauseinadults FocalSegmentalGlomerulosclerosis(15%) MembranoProliferativeGN(7%) MesangioproliferativeGN(5%) GN:Glomerulonephritis Etiology Systemiccauses(secondary25%): DM(theleadingcauseofsecondarynephroticsyndrome) ...
In the vast majority of cases, CNS is a primary glomerular disorder due to genetic defects; occasionally it can however be caused by congenital infections or alloimmune maternal disease [2]. Originally, the disorder has been referred to as the Finnish-type nephrotic syndrome due to its high ...