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MCC commonly express dot-like CK20 staining [78]. Metastasis from skin and other sites must be excluded. Thyroid NENs The vast majority of thyroid NENs are tumors of C-cells (parafollicular cells), traditionally known as “medullary thyroid carcinoma” (MTC) [79]. MTCs currently represent 3...
butPDGFRAfusions involving other partners are also identified. Cases withPDGFRBrearrangement result most commonly from t(5;12)(q32;p13.2) leading toETV6::PDGFRB; however, more than 30 other partners have been identified. Cases withFGFR1rearrangement ...
They most commonly present as spindle cell neoplasms and it can be difficult to differentiate them from other spindle cell neoplasms such as leiomyosarcomas, fibrosarcomas and synovial sarcomas. Strict criteria need to be applied in order to make the diagnosis of MPNSTs. Helpful features include ...
Most melanocytic nevi develop on sun-exposed skin during childhood and adolescence and commonly harbor mutations or, less frequently, mutations. A small subset of nevi is present at birth, and therefore must develop independently of UV l... JA Curtin,P Dan,BC Bastian - 《Journal of Investigativ...
The myeloproliferative neoplasms (MPNs), previously termed the myeloproliferative disorders, are characterized by the clonal proliferation of one or more hematopoietic cell lineages, predominantly in the bone marrow, but sometimes in the liver and spleen.1 In contrast to myelodysplastic syndromes (MDS),...
based on the phenomenon that several stress molecules in tumor cells recognized by NKG2D are commonly upregulated in solid metastatic tumors [30,51,156]. The registered ongoing clinical trials are demonstrated in Table3. Table 3 Registered ongoing clinical trials of CAR-NK treatment for solid tumor...
Although often described as characteristic of tumor headaches, the following clincial features are not commonly present [1] :Pain that is worse in the early morning than at other times Exacerbation with Valsalva maneuvers, bending over, or rising from a recumbent position ...
However, ITLP may distort, but typically does not obliterate the architecture of the involved tissues, the TdT+ cells are not as atypical as those encountered in lymphoblastic leukaemia/lymphoma, and ITLP does not show monoclonal TCR gene rearrangement. Kikuchi-Fujimoto disease (KFD) commonly ...
Per patient VCF files containing information on somatic mutations identified are available on Mendeley (doi: 10.17632/hrmxybrd2n.1) .Code availability Single-nucleotide substitutions (SNV) were called using the cancer variants through expectation maximization (CaVEMan) algorithm, version 1.13.14 (https...