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38]. The LAR subtype has highly activated hormone-related signaling pathways, including steroid synthesis, androgen and estrogen metabolism, and porphyrin metabolism pathways. Significantly, the androgen receptor (AR) and many of its downstream metabolic markers and coactivators are detected in the...
The basic structure of a cephalosporin is: Cephalosporins are divided into three groups: cephalosporin N and C are chemically related to penicillins and cephalosporin P is a steroid antibiotic resembling fusidic acid. The mechanism of action (MOA) of cephalosporins is interference with bacterial cell...
Thus, MABC/LARs are essentially characterized by AR positive IHC in the context of an absence of ER and PR expressions. AR is a member of the sex steroid hormone receptor family (like ER, PR, etc.), and it is expressed in several human tissues including the breast [28]. In the ...
of anabolic-androgenic steroids, a tendency to use several substances simultaneously, and a preferential use of substances with a high potential of causing serious side effects. These phenomena mainly concern men, with an average age of 30, and the health problems that dominate in clinical case ...
Despite the absence of expression of ER, it is characterized by highly activated hormone-related signaling pathways (including steroid synthesis, porphyrin metabolism, and androgen/estrogen metabolism). Notably, the androgen receptor (AR) is highly expressed in LAR subtype breast cancer, with its mRNA...
The androgen receptor (AR) belongs to the steroid receptor family, and acts as a nuclear transcription factor. Upon ligand binding, the AR translocates from the cytoplasm to the nucleus, where it binds to specific sequences of DNA and promotes cell proliferation [46]. The androgen receptor path...
Furthermore, we aimed to correlate PRA expression with the TNM classification; grading; histochemical subtype; FIGO (Fédération Internationale de Gynécologie et d’Obstétrique) staging and with various parameters that we previously quantified, including steroid hormone receptors; HPV proteins such as ...
Bufotalin, a steroid bufadienolide (C26H36O6), is one of the main active ingredients in the traditional Chinese medicine Chan Su, which is a dried secretion from the skin and parotid venom glands of toads (B. gargarizans) (Figure 1A) [21]. Chan Su has long been used as a cardiot...