Negative regulation of T-cell adhesion and activation by CD43 Manjunath, N., Mariangela Correa, Margarett Ardman & Blair Ardman* Department of Medicine, Division of Haematology-Oncology, New England Medical Center Hospitals, 750 Washington Street, Boston, Massachusetts 02111, USA CD43 IS a cell-...
Using brain specific CAR knockout mice (KO), we discovered an unexpected role of CAR in neuronal communication. This includes increased basic synaptic transmission at hippocampal Schaffer collaterals, resistance to fatigue, and enhanced long-term potentiation. Spontaneous neurotransmitter release and speed...
Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells. Cell. 2020;181:621–636.e622. Article CAS PubMed Google Scholar Zak TJ, Koshman YE, Samarel AM, Robia SL. Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor. ...
Control of cell cycle progression by c-Jun is p53 dependent cell cycle regulationcell proliferationmouse knockout fibroblastsp53The c-jun proto-oncogene encodes a component of the mitogern-inducible immediate-early ... M Schreiber,A Kolbus,F Piu,... - 《Genes Dev》 被引量: 2404发表: 1999年...
These results indicate that MMP-2 is involved in the regulation of cell condensation. Inhibition of MMP-2 activity by mmp-2 specific siRNA increased the protein level of fibronectin, and integrins α5 and β1. The interaction between focal adhesion kinase (FAK) and integrin β1 leading to ...
HIROSHI T; PIYANUCH S; MITSUTAKA H;.Negative ion implantation for pattering mesenchymal-stem cell adhesion on silicone rub- ber and differentiation into nerve cells with keep- ing their adhesion pattern.Surface and Coat- ings Technology.2009.2562-2565...
TNBC accounts for nearly 15–20% of all breast cancers. It is the most aggressive breast cancer subtype and leads to the poorest patient outcomes [3]. The claudin-low breast cancer subtype of TNBC has low expression levels of cell–cell adhesion molecules and high expression levels of ...
Epithelial cell adhesion molecule and epithelial-mesenchymal transition are associated with vasculogenic mimicry, poor prognosis, and metastasis of triple ... Epithelial cell adhesion molecule and epithelial-mesenchymal transition are associated with vasculogenic mimicry, poor prognosis, and metastasis of ...
For example, peroxynitrite can alter the function of transcription factors such as NFκB resulting in, altered cell adhesion mole- cule expression9. Oxidative stress can alter other transcription factors such as HIF-1αand p53 further developing the stress response, and can also increase ...
Although the mechanism for its activation was been well analyzed as described above, that for negative regulation is poorly explored. We recently reported that IKKb has a kinase-independent role in regulating widespread cellular responses and cell signaling10, implicating that there are still ...