Recent studies suggest that itaconate, a highly concerned bioactive metabolite catalyzed by immune responsive gene 1 (IRG1), is profoundly involved in the regulation of apoptosis, but the underlying mechanisms have not been fully understood. In the present study, the molecular mechanisms responsible ...
Papadakis ES , Cichon MA , Vyas JJ , Patel N , Ghali L , Cerio R , Storey A , O'Toole EA ( 2011 ) Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members . J Invest Dermatol 131 : 509 – 517...
The BL2 subtype has a unique gene expression profile characterized by the upregulation of genes associated with growth factor signaling pathways (EGFR, MET, NGF, Wnt/β-catenin, and IGF-1R) and myoepithelial markers. As well as BL1, BL2 is associated with early recurrence and metastasis. The...
Moreover, the apoptotic mechanism promoted by JNK is related to the increased expression of Fas, regulation of Bcl-2, change of intracellular Ca2+ concentration, and then the activation of caspase family. Thus, the ERK, p38, and JNK family members are closely related to cancer cell apoptosis ...
[90] explained that vitamin C enhanced the serum SOD activity via the upregulation of the mRNA of SOD. Moreover, Abdel-Latif et al. [37] indicated that dietary vitamin C (200 mg/kg diet) improved the BWG and FCR and restored plasma concentrations of cortisol, leptin, IFN-γ, TNF-α,...
As a master modulator of the DNA damage response, the regulation of cell cycle progression, repair of DNA damage, and DNA replication of CHK1 were all affected, thereby facilitating excessive damage of DNA and decreasing the fitness of overall survival of the tumor cells. 2.4. In Vivo ...
After performing a genome-wide CRISPR/Cas9 KO screen in an orthotopic breast cancer MCF7 xenograft, they found that ZNF319 could be implicated in the regulation of breast cancer progression. Gene reconstitution experiments halted TNBC growth and invasion in vitro and in vivo. Moreover, high ...
In addition, it was confirmed that the anticancer activity of bufotalin against TNBC cells was related to the regulation of the apoptosis pathway, EMT, and STAT3 signaling. Figure 1. Effect of bufotalin on the proliferation of TNBC cell lines. (A) Chemical structure of bufotalin. (B) MDA-...
Upregulation of ABC family proteins, ABCB-1 and ABCC-1 observed in DEHP-exposed clones compared to doxorubicin-resistant (DoxR) and parental MDA-MB-231 cells. A viability assay showed enhanced multidrug resistance in DEHP-exposed clones against Dox, topotecan, and irinotecan. Inhibition of ABC ...
BCFAs appear to exert their anti-inflammatory effect through the upregulation of the Zonulin (ZO-1) network and claudin-1 [43]. Alterations of tight junction proteins were associated with visceral hypersensitivity, abdominal pain, and mast cell activation. The increased GI permeability results in ...