In this work, we detail patterns of negative selection across diverse classes of regulatory elements in human 3ʹ UTRs. We introduce the intergenic MAPS (iMAPS) approach that is well-suited to detect signals of negative selection in non-coding regions of the transcriptome. Using this method, ...
the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show that this substitution confers a gain in necroptotic function in human cells, with more rapid accumulation of activated MLKLS132Pin biological membranes and MLKLS132Poverriding pharmacological...
Enhanced ROS production and antibacterial activity after Rbpj knockdown suggests Notch regulation in macrophages, and we thus sought to determine if Notch signalling directly impacts ROS production in macrophages. In support of this model, ectopic expression of the constitutively active Notch1 intracellular...
Immunotherapy has recently emerged as a treatment strategy which stimulates the human immune system to kill tumor cells. Tumor immunotherapy is based on immune editing, which enhances the antigenicity of tumor cells and increases the tumoricidal effect o
In sum, similarly to in vitro models, short-term depletion of Vps15 in vivo potentiates insulin signalling and impacts whole-body glucose metabolism. Akt signalling is augmented in hepatic mutants of Vps15. Next, we generated the liver-specific Vps15 knockout mice (herein referred as Vps15 ...
Triple Negative Breast Cancer (TNBC) is a highly heterogeneous subtype of breast cancer that lacks the expression of oestrogen receptors, progesterone receptors and human epidermal growth factor receptor 2. Although TNBC is sensitive to chemotherapy, the
Breast cancer is the most common cancer among women in the world, with the highest incidence, and is the second leading cause of cancer-related death, which has strong impacts on national economic and social development [1]. There are many kinds of breast cancers, among which triple negative...
Background: Breast and ovarian cancer stem cells (CSC) can contribute to the invasive and chemoresistance phenotype of tumors. TH1902, a newly developed sortilin (SORT1)-targeted peptide-docetaxel conjugate is currently in phase-1 clinical trial. Whether TH1902 impacts the chemoresistance phenotype ...
However, one crucial question is whether the surface charge of AuNPs impacts the natural metabolism of extracellular molecular in cells by the endocytosis pathway. Here, we fabricated a series of small-size AuNPs (13.00 ± 0.69 nm) with varied surface negative-charge densities to investigate the ...
Positive Effects of Globalization It would be rather difficult to discuss the extent of the positives that globalization has had on the world at large. But still, here are some of the positive effects of globalization and thepositive impacts they have had on so many demographic segments of socie...