Information Systems Frontiers (2023) 25:2071–2114 https://doi.org/10.1007/s10796-023-10400-x Exploring the Darkverse: A Multi‑Perspective Analysis of the Negative Societal Impacts of the Metaverse Yogesh K. Dwivedi1,2 · Nir Kshetri3 · Laurie Hughes1 ...
These cumulative impacts on the overall immune status of patients may carry substantial clinical consequences, including diminished vaccine responses, and heightened infection risks65, and are likely to influence the efficacy of cancer immunotherapy, given the pivotal role of CD8+ T cells in ...
the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show that this substitution confers a gain in necroptotic function in human cells, with more rapid accumulation of activated MLKLS132Pin biological membranes and MLKLS132Poverriding pharmacological...
Immunotherapy has recently emerged as a treatment strategy which stimulates the human immune system to kill tumor cells. Tumor immunotherapy is based on immune editing, which enhances the antigenicity of tumor cells and increases the tumoricidal effect o
Triple Negative Breast Cancer (TNBC) is a highly heterogeneous subtype of breast cancer that lacks the expression of oestrogen receptors, progesterone receptors and human epidermal growth factor receptor 2. Although TNBC is sensitive to chemotherapy, the
R. Otitis media impacts hundreds of mouse middle and inner ear genes. PLoS One 8, e75213 (2013). 17. Thornton, R. B. et al. Neutrophil extracellular traps and bacterial biofilms in middle ear effusion of children with recurrent acute otitis media–a potential treatment target. PLoS One 8...
Breast cancer is the most common cancer among women in the world, with the highest incidence, and is the second leading cause of cancer-related death, which has strong impacts on national economic and social development [1]. There are many kinds of breast cancers, among which triple negative...
Background: Breast and ovarian cancer stem cells (CSC) can contribute to the invasive and chemoresistance phenotype of tumors. TH1902, a newly developed sortilin (SORT1)-targeted peptide-docetaxel conjugate is currently in phase-1 clinical trial. Whether TH1902 impacts the chemoresistance phenotype ...
However, one crucial question is whether the surface charge of AuNPs impacts the natural metabolism of extracellular molecular in cells by the endocytosis pathway. Here, we fabricated a series of small-size AuNPs (13.00 ± 0.69 nm) with varied surface negative-charge densities to investigate the ...
Positive Effects of Globalization It would be rather difficult to discuss the extent of the positives that globalization has had on the world at large. But still, here are some of the positive effects of globalization and thepositive impacts they have had on so many demographic segments of socie...