colon cancer clinical researchcolonoscopyoutcome researchFecal immunochemical testing (FIT) is used as a screening tool because of its adequate sensitivity to detect colorectal cancer (CRC). Whether individuals with negative baseline FIT results have a low risk of CRC over a long period of follow-up...
SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis. J Clin Invest. 2023;133:e162870. Article CAS PubMed PubMed Central Google Scholar Li L, Kang J, Zhang W, Cai L, Wang S, Liang Y, et al. Validation of NEDD8-conjugating enzyme UBC12 as a...
supervised ML methods were applied to predict cancer driver genes [17,18], to distinguish between cancer types [19,20], and to predict gene dependency in tumors [21]. However, ML has not been
Cancer stem cells (CSCs) have the potential to self-renew and induce cancer, which may contribute to a poor prognosis by enabling metastasis, recurrence, and therapy resistance. Hence, this study was performed to identify the association between CSC-rela
processes. However when dysregulated, it is linked to self-renewal and radiotherapy resistance in GBM81, increased stemness in colon cancer and gliomas82,83and altered ATP metabolism which has been implicated in TNBC metastasis84. Despite their importance in cancer cell functions, the precise ...
Triple-negative breast cancer ranks among the most aggressive types of breast cancer, and its name is attributed to the lack of three major receptors conventionally targeted for breast cancer treatment. These include receptors for HER2 (epidermal growth factor), estrogen and progesterone. The exact ...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast neoplasms with a higher risk of recurrence and metastasis than non-TNBC. Nevertheless, the factors responsible for the differences in the malignant behavior between TNBC and no
In Chow's test, the optimal cutoff point for node-negative colon cancer was 15, which was validated in both cohorts after controlling for confounders (Surveillance, Epidemiology, and End Results database: hazard ratio: 0.701, p < 0.001; single-center: HR: 0.563, p = 0.031). Conclusions: ...
Breast cancer is the most frequently diagnosed malignancy among women, and triple-negative breast cancer (TNBC) is a highly aggressive subtype. Increasing evidence has shown that lncRNAs are involved in tumor growth, cell-cycle, and apoptosis through interactions with miRNAs or mRNAs. However, there...
Colon cancer-associated transcript-1 (CCAT1), an lncRNA, which was first identified in colon cancer, was previously shown to promote tumor development and be a negative prognostic factor in gastric cancer. However, the mechanism through which CCAT1 exerts its oncogenic activity remains largely ...