1.4 Physiology of the Endocannabinoid System 1.4.1 Mechanisms Underlying the Retrograde Control of Synaptic Signaling Endocannabinoids, particularly 2-AG, act as retrograde messengers in the CNS. This negative feedback mechanism is conserved at glutamatergic synapses in the spinal cord, midbrain, striatum...
Actually, most diselenides are excellent catalysts for this reaction, presumably through the generic mechanism depicted in Fig. 239. The essence of the mechanism is that selenols are oxidized much faster than thiols, and that a very fast thiol-diselenide exchange can quickly regenerate selenols43...
Further, we demonstrate that this negative feedback loop of NO production control is dependent on the Nrf2-Keap1 signaling pathway. Taken together, the careful regulation of NO production by 4-HNE argues for a more fundamental role of this lipid peroxidation product in normal physiology.Tonibelle...
Previous studies have shown that trypsin and chymotrypsin in the duodenum exert a negative-feedback regulation on pancreatic enzyme secretion in the rat. The mechanism responsible for this physiological phenomenon is unknown. By use of a... DS Louie,D May,P Miller,... - 《American Journal of...
While powerful, there are caveats to using KERKO mice to understand the mechanism of estrogen negative feedback; normal pathways of estradiol action are very likely altered during development following Esr1 deletion26,27 and, in addition, Esr1 is deleted in all kisspeptin-expressing cells in the ...
TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates Gq Protein–Coupled Receptor–Induced Vasoconstri... TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates Gq Protein–Coupled Receptor–Induced ...
Regulation of noradrenaline release in the rat pineal through a negative feedback mechanism mediated by presynaptic α-adrenoceptors 来自 Elsevier 喜欢 0 阅读量: 11 作者: F. Pelayo and M.L. Dubocovich and S.Z. Langer DOI: 10.1016/0014-2999(77)90018-8 年份: 1977 收藏 引用 批量引用...
We have not found any neurofunctional studies involving patients suffering from conversion deafness or aphonia during the acute episode. In our opinion, hysterical deafness could have a common underlying mechanism with other negative conversion symptoms. Functional/conversive dysphonia and aphonia are heter...
Intracellular Ca2+ oscillations generated via the Ca2+-sensing receptor are mediated by negative feedback by PKCα at Thr888. To clarify the mechanism(s) underlying intracellular Ca(2+) concentration ([Ca(2+)]i) oscillations induced by an elevation in extracellular Ca(2+) concentr... SH Youn...
,... - 《American Journal of Physiology Cell Physiology》 被引量: 12发表: 2007年 NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB. Moreover, overexpression of a dominant-negative mutant of JNK1...