design in naturedouble-negative feedback loopsdnflsmotiftranscriptional networksstochastic simulationsThe gene networks that regulate the choice of cell fate in living organisms contain a set of ubiquitous design motifs. We discuss the role of one such motif, the double-negative feedback loop, in ...
However, negative feedback loop motifs are unavailable for thiol chemistry. Here, we develop a negative feedback loop based on the selenocarbonates. In this system, thiols induce the release of aromatic selenols that catalyze the oxidation of thiols by organic peroxides. This negative feedback ...
which provide them with lipids and sugars in exchange for phosphorus and nitrogen. Nutrient exchange must be dynamically controlled to maintain a mutually beneficial relationship between the two symbiotic partners. The WRI5a and its homologues play a conserved role in lipid supply to AMF. Here, we ...
1 Scientific RepoRts | 7:42006 | DOI: 10.1038/srep42006www.nature.com/scientificreportsNF-κB regulates neuronal ankyrin-G via a negative feedback loopHans-Georg König 1,2 , Robert Schwamborn 1,2,† , Silke Andresen 1 , Sinéad Kinsella 1,2 , Orla Watters 1,2 , Beau Fenner 1,...
In turn, E2Fs activate the expression of SNI1, suggesting that E2Fs and SNI1 form a negative feedback loop. Genetically, overexpression of SNI1 suppresses the phenotypes of E2F-overexpressing plants, and loss of E2F function fully suppresses the sni1 mutant, indicating that SNI1 is necessary ...
- 《Nature Immunology》 被引量: 313发表: 2010年 NKT Cells Provide Help for Dendritic Cell-Dependent Priming of MHC Class I-Restricted CD8+ T Cells In Vivo Dendritic cells (DC) are potent APCs for naive T cells in vivo. This is evident by inducing T cell responses through adoptive DC ...
Gene-silencing of p65 or ankyrin-G overexpression suppressedreporter activity. Collectively these data demonstrate that p65/NF-κB controls ankyrin-G levels via a negative feedback loop, thereby linking NF-κB signaling with neuronal polarity and axonal plasticity. 展开 ...
If hypermethylation-associated silencing ofSOCS-1occurs in tumor cells, this negative feedback loop is disrupted, and consequently those cells may become more responsive to stimulation by cytokines and growth factors that use the Jak/STAT pathway for signal transduction. In MM pathogenesis, IL-6 ...
The development of the b-process equals the development of a negative affective state and withdrawal symptoms, in opposition to the hedonic quality of the unconditioned stimulus. Importantly, the nature of the acquired motivation is specified by the nature of the b-process, that is, an aversive...
As targets of miR-17-92, E2F transcription factors family has been suggested to induce the transcription of miR-17-92 in several cell types. In the present study, we sought to investigate whether this negative feedback loop exists in mouse PMCs and what the function of this negative feed...