Although polymyxins have antibacterial potential, they still have low stability and adverse effects, thus limiting their administration. To overcome these limitations, the use of controlled release systems such as liposomes, nanoparticles, and nanotubes is a viable strategy. Therefore, the objective of ...
Breathing is an automatic, unconscious act until it is not sufficient—when symptoms of breathlessness and distress develop, or when life itself is threatened. All normal breathing is by negative pressure, accomplished by the development of negative intrathoracic, or below atmospheric pressure, when th...
1e–g). The effects of SMO inhibition on tumor growth and gene expression were not observed in control tumors lacking Hh expression (M6-Ctrl) or in benign adult mouse mammary gland (Supplementary Fig. 1b, g, h), reflecting on-target drug activities. Similar results were observed with the...
Chemokines mainly act by recruiting neutrophils to the site of infection. While the appropriate neutrophil response is critical for the removal of the invading pathogen, excess inflammation can lead to tissue damage and perpetuate inflammation leading to detrimental effects, as seen across several ...
Current anti-inflammatory therapies act via suppressing the positive signaling pathways involved in the production of inflammatory mediators. However, prolonged use of these drugs could have severe side effects because these pathways are also involved in mediating physiological responses. Therefore, therapeuti...