Prepulse inhibition of acoustic startle is a behavioural response, which is used to estimate sensorimotor gating deficits in schizophrenia. Recent studies show that several behavioural effects of the psychotomimetic drug, phencyclidine (PCP), in rodents are blocked by nitric oxide synthase (NOS) inhibi...
Phencyclidine (PCP, "angel dust") induces a psychotomimetic state that closely resembles schizophrenia. As opposed to amphetamine-induced psychosis, PCP-in... None - 《American Journal of Psychiatry》 被引量: 5055发表: 1991年 Phasic versus tonic dopamine release and the modulation of dopamine sys...
Further, MTEP, but not M-5MPEP, potentiated the discriminative-stimulus effects of PCP. The present data suggest that partial mGlu5 NAM activity is sufficient to produce therapeutic effects similar to full mGlu5 NAMs, but with a broader therapeutic index....
planning process.Findings:Three superordinate themes emerged from the IPA analysis: 1) the negative aspects of the discharge planning process 2) focus on ... Natalie O'Hana 被引量: 0发表: 2019年 Study on the Negative Effects of Plants in Urban Green Planning Based on the Experts and Public...
Further, MTEP, but not M-5MPEP, potentiated the discriminative-stimulus effects of PCP. The present data suggest that partial mGlu5 NAM activity is sufficient to produce therapeutic effects similar to full mGlu5 NAMs, but with a broader therapeutic index. Neuropsychopharmacology (2016) 41, 1166...
OBJECTIVE--To determine the factors associated with the occurrence of Pneumocystis carinii pneumonia (PCP) in Wegener's granulomatosis (WG). METHODS--We re... B Godeau,JL Mainardi,F Roudot-Thoraval,... - 《Annals of the Rheumatic Diseases》 被引量: 52发表: 1995年 AIDS incidence and AIDS-...
Here we present a 2.9-Å-resolution crystal structure of human BRAFKD in complex with MEK and the ATP analog AMP-PCP, revealing interactions between BRAF and ATP that induce an inactive, monomeric conformation of BRAFKD. We also determine how 14-3-3 relieves the negative regulatory effect ...
We used deep autoencoders to investigate the effect of different sampling approaches for non-interacting pairs on the training and the performance of machine learning classifiers. By using the anomaly detection capabilities of deep autoencoders we deduced the effects of different categories of negative...
Furthermore, discovery of a novel, systemically active M1 positive allosteric modulator (PAM), VU0453595, allowed us to evaluate the impact of selective potentiation of M1 on induction of LTD and behavioral deficits in PCP-treated mice. Interestingly, VU0453595 fully restored impaired LTD as well ...
The inhibitory effects of sFRP1 on β-catenin/Tcf activity were prevented by co-expression of Wnt3a (Figure 3A). We next examined the effect of Wnt3a on sFRP1 repression of AR activity and found that despite preventing sFRP1 repression of β-catenin/Tcf activity, Wnt3a did not affect sF...