Genetic engineering via negative fitness is ablock pivoting procedure which either delivers a certificate for global optimality of thecurrent local solution, or else enables an escape from its basin of attraction, if it is inefficient.The name originates from the way the block pivot is obtained: ...
Genetic(基因的)engineering is the scientific change of the genetic material in a living organism. It allows scientists to identify specific genes, to remove them from an organism's chromosomes (染色体), improve them, analyze them, and possibly clone them, and to then reinse...
Dominant-negativemutationscan have a wide range of effects, depending on the protein that is affected. For example, in certain types of cancer, dominant-negative mutations in tumor suppressor genes can lead to the development of tumors. In other cases, dominant-negative mutations can result in de...
School of Life Sciences, Tsinghua University, Beijing 100084, China; 2State Key Labo- ratory of Genetic Engineering and Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China; 3College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ...
Heterosis, maternal and direct effects in double-muscled and normal cattle: II. Carcass traits of young bulls. J Anim Sci. 1989;67:911–9. Article CAS PubMed Google Scholar Bougas B, Granier S, Audet C, Bernatchez L. The transcriptional landscape of cross-specific hybrids and its ...
(1983). A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram-negative bacteria. Bio/ Technology 1, 784-... AD Sharrocks,J Green,JR Guest - 《Proceedings of the Royal Society B Biological Sciences》 被引量: 141发表: 1991年 The Genetic Basis ...
At this juncture, it was of interest to investigate the global effects of IL-4 during reinforcement stage of Th2 differentiation. We deployed similar neutralization strategy as in Figure 1a. Whole genome tran- scription profiling was done to identify the target of IL-4 and even- tually novel...
The observed functional effects of BPAM344 were consistent with the results of the previous functional experiments22 and confirmed its positive allosteric modulation of GluK2. Download: Download high-res image (2MB) Download: Download full-size image Figure 1. Positive allosteric modulation of GluK2...
Gene expression via transcription-translation is the most fundamental reaction to sustain biological systems, and complex reactions occur in a small compartment of living cells. There is increasing evidence that physical effects, such as molecular crowdi
We have developed a new vector strategy for the insertion of foreign genes into the genomes of gram negative bacteria not closely related to Escherichia coli. The system consists of two components: special E. coli donor strains and derivatives of E. coli