Based on these experiences, we analyzed the problems of homeochemotherapy. The rate of negative side effects was 15.1% with CHAI. More than half were cases of abdominal pain. Because we had established an observation system for emergency cases, there were no fatal accidents. With FP therapy, ...
Chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2-negative (or unknown) advanced breast cancer: American Society of... PURPOSE: To identify optimal chemo- and targeted therapy for women with human epidermal growth factor 2 (HER2)- negative (or unknown) ...
Chemotherapy, usually with high toxicity, is the main treatment option for TNBC. However, despite the ability of some chemotherapeutic agents to cross the blood-brain barrier (BBB), brain metastases show pronounced resistance [3]. Accordingly, there is an unmet need to identify novel molecular ...
2007). Although targeted therapies are becoming part of first line treatments for a number of cancers, sequential chemotherapy remains the standard of care for TNBC, due to the lack of receptor expression for targeting (Lee and Djamgoz 2018; Székely et al. 2017). Poly-(ADP-ribose) ...
To confirm the in vivo finding, we examined the effects of tumor cell conditioned medium on C/EBPα expression in vitro. We cultured 32D murine myeloid cells in fresh medium or medium conditioned by 3LL tumor cells (TCM). C/EBPα expression was significantly reduced by more than 40% after...
Anti-Netrin-1 decorated nanoparticles combined with chemotherapy for the treatment of triple-negative breast cancer Docetaxel-loaded nanoemulsions (NEs) binding an anti-netrin-1 monoclonal antibody were optimized.PEGylated surfactants that stabilize NEs affected the effi... S Breusa,E Thomas,N Baldino...
Since they are missing these molecular targets, TNBCs are treated with various combinations of general cytotoxic chemotherapy agents as the primary treatment6. Thus, there is an unmet clinical need to develop treatments for TNBC that are both effective and have fewer toxic side effects. CREB3 (...
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer, negatively expresses estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2). Although chemotherapy is the main form of treatmen
Up to 20 percent of invasive breast cancers are classified as triple negative, which refers to the fact that the cells are estrogen receptor negative (ER-), progesterone receptor negative (ER-), and HER2 negative. Treatments that reduce the production of estrogen or block its effects are not ...
Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic agents and also ameliorates CT-associated adverse effects. However, the...