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4g). Thus, lack of HuR results in increased adipogenesis and browning in iWAT. HuR depletion resulted in browning in iWAT but inflammation in eWAT, suggesting that HuR may play different roles in distinct depots. To analyze the depot-specific effects of HuR knockout, we compared the altered ...
To induce IgG1 or IgE isotype switching, LPS plus IL-4 (25 ng/mL; Peprotech) were used with daily addition of 500 ng/mL anti–interferon γ neutralizing Ab (R4-6A2) or 500 ng/mL rat IgG1 (R3-34). After 6 days of culture, cells were collected and stained with either biotin-...
Peptide-MHC complexes were multimerized by the addition of streptavidin APC conjugate (Invitrogen, Eugene, OR, USA) and PE streptavidin (BioLegend, CA) followed by adding D-biotin after incubation. Multimer and live/dead AF488 were used to stain peptide-stimulated T cells. Tetramer-positive ...
However, the precise effects of nomilin on the proliferation, viability, and metastasis of TNBC remain incompletely elucidated. Additional investigations are warranted to delineate and elucidate the specific effects that nomilin may have on this particular type of BRCA. The complex array of targets ...
Steroidal glycoalkaloids (SGAs) are major plant defense metabolites against pests, while they are considered poisonous in food. The genetic basis that guides negative selection of SGAs production during tomato domestication remains poorly understood. Her
Triple negative breast cancer (TNBC) exhibits higher susceptibility towards oxaliplatin (OXA) due to a faulty DNA damage repair system. However, the unfavorable physicochemical properties and risk of toxicities limit the clinical utility of OXA. Therefore, to impart kinetic inertness, site-specific deli...
Recently, we identified novel protein interactors of the EcR/Usp heterodimer using in vivo proximity-dependent biotin ligation2, including the NELF-A subunit. We validated this interaction in a previous report by co-immunoprecipitation of these proteins from the prepupal nuclear extract (where the ec...
The sequences of the protein bands were analyzed using LC/MS/MS analysis (Korea Basic Science Institute, Seoul, Korea). For RNA pull-down experiments, we also used biotin-labeled wild-type or mutant Hr 5′ UTR probes with HEK293T cell lysates prepared from the cells transfected with FLAG-...
The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.Inventors...