Healthy undergraduate students (64.7% women, age M = 18.15, SD = 3.33) were randomly assigned to ingest 1,000 mg of acetaminophen or placebo before completing emotional picture viewing (n = 143), a flanker task (n = 69), and a probabilistic learning task (n = 143) while EEG was ...
The possible cytotoxic effects of the released drugs on the liver, kidney, and lung are assessed using quantitative biochemical assay from blood samples of the treatment groups. Ex vivo histopathological results from organ tissues showed that the targeted cancer drugs released from the implantable drug...
15, 16 Hepatic LSECs are sensitive to both oxidative stress17 and the effects of LPS18, 19 and pyocyanin.16, 20 Owing to the role of the LSEC in liver allograft rejection21 and hyperlipidemia,22, 23 cellular and biochemical changes induced by Gram-negative bacterial toxins may have ...
we also found that SLE patients exhibited an accumulation of DN T cells with reduced apoptosis. Furthermore, comparing the DN T cells from SLE groups with the healthy control, we discovered that the neddylation level of Cullin1 was enhanced while Bim level ...
Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide, in which mitochondrial DNA (mtDNA) released by damaged hepatocytes activates neutrophils through binding of Toll-like receptor 9 (TLR9), further aggravating liver injury. Here, we demonstrated that mtDNA/TLR9 also ...
Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide, in which mitochondrial DNA (mtDNA) released by damaged hepatocytes activates neutrophils through binding of Toll-like receptor 9 (TLR9), further aggravating liver injury. Here, we demonstrated that mtDNA/TLR9 also ...
In vitro experiments revealed that miR-223-deficient neutrophils were more susceptible to TLR9 agonist-mediated induction of pro-inflammatory mediators and NF-κB signaling; whereas overexpression of miR-223 attenuated these effects in neutrophils. Moreover, inhibition of TLR9 signaling via either ...
AcetaminophenExisting data suggest that antipyretic medications may have deleterious effects on immune function and may increase mortality in human infection. This study was designed to evaluate the impact of antipyretic therapy on 28-day in-hospital mortality when administered early in the course of ...
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Abbreviations AP allopurinol; APAP acetaminophen; APS astragalus polysaccharide; α-SMA α-smooth muscle actin; BMP-7 bone morpho...