The incidence of hospital-acquired infections with multidrug-resistant (MDR) Gram-negative pathogens is increasing at an alarming rate. Equally alarming is the overall lack of efficacious therapeutic options for clinicians, which is due primarily to the acquisition and development of various antibiotic ...
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No effect was seen in parental reports. Both qualitative data from focus group interviews with students and questionnaires for teachers supported the view that the students benefited from the program. Overall, these results demonstrate a positive effect of the positive education program on increasing ...
The disordered N-terminal domain and phosphorylated residue of HDAC6 facilitate effective LLPS, whereas nuclear export regions exert a negative dominant effect. Through phase-separation-based screening, we identified Nexturastat A as a specific disruptor of phospho-HDAC6 condensates, which effectively ...
This allows for cytotoxic SN-38 liberation in the acidic tumor microenvironment without prerequisite internalization and subsequent enzymatic cleavage22, enabling “bystander effect” tumor cell killing23. Upon binding, its drug-antibody ratio of 7.6:1 allows the release of a high localized SN-38 ...
病原微生物学教学课件:9- Gram Negative Bacilli.pptx,Gram Negative BacilliCurriculum centerGram Negative BacilliEnterobacteriaceae 肠杆菌科Vibrio 弧菌属Helicobacter pylori 幽门螺杆菌Campylobacter jejuni 空肠弯曲菌Brucella 布鲁菌属Y. pestis 鼠疫耶尔森菌P.
K Mcdonough - 《Studies in Second Language Acquisition》 被引量: 393发表: 2005年 自然是完美教育的最好诠释——新标准英语第11册Module 9 Unit 1 Do youwant to visit the UN building 教学设计 According to the requirements of the New English Curriculum Standard, the teaching activities in primary ...
shares anonymized individual patient data upon request or as required by law or regulation with qualified external researchers based on submitted curriculum vitae and reflecting non-conflict of interest. The request proposal must also include a statistician. Approval of such requests is at the ...
an antibody component with high specificity for Trop-2, a high drug-to-antibody ratio (7.6:1), the fact that internalization and enzymatic cleavage of SG by tumor cells is not required for SN-38 liberation from the antibody, and its bystander effect in tumor microenviroment15,16,17,18,19...
Table 3 The direct effect of FLB, FLA, and L2 demotivation on online and in-person L2WTC Full size table Fig. 1 The structural model of the study.L2WTC. Note: FLA: Foreign Language Anxiety; FLB: Foreign Language Boredom; TB: Teacher Behavior; CC: Classroom Characteristics; CE: Classroom...