negative double stranded DNA, anti-Smith antibodies, lupus nephritisSystemic lupus erythematosus (SLE) is an autoimmune disease in which auto-antibodies are generated against a variety of intracellular antigens. Anti-Smith (Sm) and anti-double stranded DNA (dsDNA) antibodies in particular are ...
Laboratory studies included an antinuclear antibody (ANA), rheumatoid factor (RF), complement C3 and C4, human immunodeficiency virus 1 and 2 (HIV 1 and 2) antibody, antineutrophil cytoplasmic antibodies (ANCA), anti-double-stranded DNA (anti-dsDNA) antibodies, and anti-GBM antibodies. All were...
Rheumatoid factors (RF) were detected in 36.7%, antinuclear antibodies (ANA) in 11.7%, antibodies (IgG and/or IgM) against cardiolipin (anti-CL) and double stranded DNA (anti-ds DNA) in 20% and 50%, respectively. RF, ANA, anti-CL and anti-dsDNA antibodies were also detected in the ...
In this report, we examined whether immunofluorescent anti-nuclear antibody (FANA) test could be used as an initial screening test in identifying serum samples where subsequent testing for antibodies to extractable nuclear antigens (ENA) and to double-stranded DNA (ds-DNA), would be worthwhile. ...
Most fungal viruses have either double-stranded RNA (dsRNA) or positive-strand (+)ssRNA genomes, however, recent reports have expanded our knowledge of fungal virus diversity by findings of fungal viruses with monopartite (−)ssRNA (family Mymonaviridae, in the order Mononegavirales) and ssDNA ...
Due to the high immunogenicity of bacterial DNA and shared epitopes with mammalian DNA, rapid degradation of bacterial DNA would be important in this location to avoid potential pathogenic anti- DNA antibody formation, possibly involving the adjacent DN2 B cells. To assess the presence of bacteria...
Antibody–drug conjugate (ADC) In recent years, research on ADC is in full swing. ADC mainly uses antibodies as carriers to deliver cytotoxic drugs into tumor cells, breaking double-stranded DNA and further leading to tumor cell death, thus achieving high tolerance and enhanced cytotoxic effects ...
(I:C) or reovirus, and Trim21 might have a much more important effect on the innate immune response to intracellular double- stranded DNA, as 1.5- to 4-fold more IFN-b was observed in Trim21-deficient BMDCs in response to poly(dA:dT), vac- cinia virus DNA, adenovirus and herpes ...
The GFP donor template targeting the CD45 locus, provided either as single-stranded DNA (in single-strand AAV; ssAAV) or as double-strand DNA (in self-complementary AAV; scAAV) showed a comparable increase in HDR with SaCas9-DN1S as compared to SaCas9 (both SaCas9 and SaCas9-DN1S we...
Antibody–drug conjugate (ADC) In recent years, research on ADC is in full swing. ADC mainly uses antibodies as carriers to deliver cytotoxic drugs into tumor cells, breaking double-stranded DNA and further leading to tumor cell death, thus achieving high tolerance and enhanced cytotoxic effects ...