The present case challenges the notion that a negative C-11 PIB scan excludes AD and argues for a comprehensive diagnostic workup.doi:10.1097/rlu.0b013e3182335e08Hellwig, SabineHüll, MichaelMeyer, Philipp T.Clinical Nuclear MedicineHellwig S, Hu¨ll M, Meyer PT (2011) Negative amyloid PET ...
Abbreviations: Aβ amyloid-β, CSF cerebrospinal fluid, CU cognitively unimpaired, CI cognitively impaired, p-Tau phosphorylated tau, WMH white matter hyperintensities Full size image Associations of voxel-wise FDG PET images with CSF p-Tau/Aβ40 and its significant risk factors were analyzed using...
It might be worthwhile to consider genetic screening of lvPPA patients in cases with a positive family history or where AD pathology is deemed to be less likely, such as those with a normal CSF biomarker profile or a normal amyloid PET. In recent years, genetic testing has become an ...
We prospectively recruited 29 amyloid-positive ADCI patients, 28 amyloid-negative SVCI patients that were confirmed by 11 C-PiB-PET scan and 34 individuals with normal cognition (NC). The three groups were compared in terms of retinal vascular variables (retinal fractal dimension, vascular caliber,...
Amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the core features of Alzheimer’s disease (AD) [1]. According to the NIA-AA research framework [2], individuals with evidence of Aβ pathology are on the Alzheimer’s disease continuum, while Aβ-negative (Aβ−) individuals ...
Background: Studies have showed that B-amyloid plaques are likely to only exhibit local affects on the cortex at early stages of the disease before or when early cognition impairments occur. Understanding when and where neurodegeneration starts in the cortex may provide insights into the pathogenesis...
Significance of a positive tau pet scan with a negative amyloid pet scandoi:10.1002/alz.082370Robinson, Carling G.Lee, JeyeonMin, Paul HPrzybelski, Scott A.Josephs, Keith AJones, David T.Radford, Jonathan GraffBoeve, BradKnopman, David S....
CLINICALLY DIAGNOSED PROBABLE AD CASES WITH A NEGATIVE AMYLOID PET SCAN: CLINICAL FINDINGS - Alzheimer's & Dementia: The Journal of the Alzheimer's Associationdoi:10.1016/j.jalz.2014.04.388Rabinovici, Gil DanOssenkoppele, RikPerrotin, Audrey...
doi:10.1097/01.NT.0000532693.75769.74Fitzgerald, SusanNeurology Today
AMYLOID PET IS MORE THAN JUST POSITIVE OR NEGATIVE: AMYLOID LEVEL IMPACTS RISK OF CLINICAL PROGRESSION IN NORMAL INDIVIDUALSdoi:10.1016/j.jalz.2019.06.4763Laura M. van Der KallSamantha C. BurnhamVincent DoreRachel S. MulliganChristopher Rowe