single agent, similar to what would be expected with polychemotherapy (45%)62. In the TNBC subset of a small randomized phase II trial, GeparOla, paclitaxel plus olaparib had similar pCR rate, and better toxicity, as paclitaxel plus carboplatin in patients with early somatic or gBRCA1/2 muta...
The product-ion ESI mass spectrum of protonated psychosine was acquired using a triple quadrupole mass spectrometer (TSQ Quantum Ultra Plus, ThermoFisher Scientific, San Jose, California, USA). Collision activation was carried out with collision energy of 24 eV and gas pressure of 1 mTorr. The...
Thus the current direction of search is a combination of the current negative gradient plus a scalar β times the previous direction of search. The crucial question is: how is the value of β to be determined? The criterion used is that successive directions of search should be conjugate. Thi...
Triple-negative breast cancer (TNBC) has few therapeutic targets, making nonspecific chemotherapy the main treatment. Therapies enhancing cancer cell sensitivity to cytotoxic agents could significantly improve patient outcomes. A BCL2-associated agonist
2009;3:046002. Article CAS PubMed Google Scholar Millonig G, Praun S, Netzer M, Baumgartner C, Dornauer A, Mueller S, et al. Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study. Biomarkers. 2010;15...
Methods : Three patients aged 16, 19, and 65 years with a 13-to 36-year history of partial epilepsy were receiving a therapeutic dosage of carbamazepine or phenobarbital plus either clobazam (CLB) or valproate (VPA). None had previously had ENM. Forty-eight to 72 h after CLB or VPA ...
Three model selection strategies were chosen for the application of the RP test for outlier detection based on TNBC gene expression data plus the significant clinical variables identified above: i) variable selection by sparse logistic regression using EN regularization, herein called LOGIT-EN; ii) va...
Breast cancer is the most common malignancy for women worldwide, while Triple Negative Breast Cancer (TNBC) accounts for 20% in all patients. Compared with estrogen receptor positive breast cancer, which could be effectively controlled via endocrine ther
Researchers have found that the markups earned by mortgage brokers were persistently higher on negative point loans than on positive point loans. A study conducted byThe Mortgage Professorat the turn of the century found that on loans quoted by thelenderat 6% plus 3 points, the markup to the ...
Parents were recruited from a pediatric nephrology clinic and randomly assigned to one of two treatment groups: usual support for home-based clinical caregiving (control) or usual support plus password-protected access to OPIS for 20 weeks... VM Swallow,K Knafl,SJ Sanatacroce,... 被引量: 3...