Nedocromil sodium, disodium9-ethyl-6, 9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3, 2-g]quinoline-2,8-dicarboxylate (Tilade), is structurally relatedto cromolyn and displays similar, but broader, pharmacologicalactions. It was available as an aerosol in ametered-dose inhaler for asthma treatment...
Patients were randomized to either a nedocromil sodium metered dose inhaler, 4 mg, four times daily, or placebo for 12 weeks. Clinical symptoms, lung function tests and sputum characteristics of volume, purulence, leucocyte count, neutrophil chemotactic activity and elastolytic activity were evaluated...
Define nedocromil. nedocromil synonyms, nedocromil pronunciation, nedocromil translation, English dictionary definition of nedocromil. n. An anti-inflammatory drug, C19H15N, used in an inhaler in the form of a sodium salt to treat mild-to-moderate asthma
Tilade Inhaler (nedocromil sodium inhalation aerosol) is a pressurized metered-dose aerosol suspension for oral inhalation containing micronized nedocromil sodium and sorbitan trioleate, as well as dichlorotetrafluoroethane and dichlorodifluoromethane as propellants. Each Tiladecanister contains 210 mg nedocrom...
2. Nedocromil sodium (4 mg, 7.8 10(-6) M), sodium cromoglycate (10 mg, 24.1 10(-6) M) and matched placebo were administered by identical metered dose inhalers 30 min before a dose-response to sodium metabisulphite (5-100 mg ml-1) was performed. 3. Maximum fall in sGaw after ...
Spezia E, De! Col G. Richelli C. Sette L, Boner AL: Nedocromil sodium vs sodium cromoglycate pres- surized aerosol in the prevention of bronchoconstric- tion induced by ultrasonic nebulized distilled in asthmatic children. Pediatric Pulmonology 1993; 16: 243-247....
dry powder inhaleremitted dosefine particle dosefine particle fractionmass median aerodynamic diameternedocromil sodium trihydratenedocromil sodium heptahemihydraterelative humidityscanning electron microscopyPrevious investigations have found that the in vitro aerosol performance of nedocromil sodium is poor. A ...
nedocromil sodium trihydrateNedocromil sodium trihydrate is not amenable to conventional methods of dry powder inhaler formulation, including the preparation of coarse carrier systems and aggregation of the pure drug powder. It is considered that the in vitro aerosol performance of such systems is ...
sodiumtwicedailydosingThe efficacy and safety of nedocromil sodium inhalation aerosol (4 mg*** Each actuation delivers 2 mg ex-valve and 1.75 mg from the mouthpiece. of Tilade administered by metered-dose inhaler) given twice daily was compared with placebo in 112 patients with mild-to-moderate...
The aerosol properties of dry powder inhaler formulations of micronized and milled nedocromil sodium were investigated. Milled and micronized drug, alone or with a carrier (α‐lactose monohydrate) were filled into hard gelatin capsules. These were placed into a proprietary dry powder inhaler device,...