作者通过相互作用分析,确定了一套免疫调节网络,并发现NECTIN2-TIGIT也是核心免疫检查点之一。联合阻断TIGIT和PD-L1可以显著减少了体内神经母细胞瘤的生长,实现了完全响应(complete responses,简称CR)。此外,在化疗耐药的Th-ALKF1174L/MYCN 129/SvJ...
其中NK细胞具有细胞毒性降低的表型,而T细胞则显示功能失调。作者通过相互作用分析,确定了一套免疫调节网络,并发现NECTIN2-TIGIT也是核心免疫检查点之一。联合阻断TIGIT和PD-L1可以显著减少了体内神经母细胞瘤的生长,实现了完全响应(complete responses,简称CR)。此外,在化疗耐药的Th-ALKF1174L/MYCN 129/SvJ同种移植模型...
近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文章,通过单细胞RNA测序技术,深入探索了神经母细胞瘤的免疫微环境。作者通...
近日,来自荷兰Princess Máxima Center for Pediatric Oncology的Judith Wienke研究组在Cancer Cell上发表题为Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy的文章,通过单细胞RNA测序技术,深入探索了神经母细胞瘤的免疫微环境。 为了...
Using a mutagenesis approach, we dissected the energetic basis for the TIGIT/nectin-2 interaction and revealed that an "aromatic key" of nectin-2 is critical for this interaction, whereas variations in the lock were tolerated. Moreover, we found that the C-C loop of the ligand dictates the...