EMSA and ChIP assays showed that Cd inhibits the binding of positive regulators to nectin-2 promoter. siRNA and overexpression analyses have demonstrated that Cd reduces the expression and binding affinity of positive regulators for transcription. Taken together, nectin-2 is the direct molecular target...
Nectin-like molecule 2 (Necl-2)/cell adhesion molecule 1 (CADM1) is shown to be down-regulated by the promoter hypermethylation and/or loss of heterozygosity at chromosome 11q23.2 in many types of cancers, including lung and breast cancers, and is proposed to serve as a tumor suppressor....
Necl-2 is down-regulated by the hypermethylation of the Necl-2 gene promoter and/or loss of heterozygosity at chromosome 11q23.2 in many types of cancers, such as lung and breast cancers, and is proposed to serve as a tumor suppressor (2, 3, 11). However, the incidence of these epig...