While commonly used cholesterol-lowering drugs such as statins have a moderate stimulatory effect on HDL, Fibrate and prescription-strength Niacin (which can also be obtained in the everyday diet) can effectively increase HDL levels48 and this has implication for LNP dosing and performance. In ...
The basic strategy of Jewish group antagonism is to take a good idea, necessary to group defense, advocacy, homeostasis, and deploy it in the interest of non-Whites or anti-Whites; then exaggerate or reverse these advocacy concepts to the point of utter misrepresentation, absurd...
These groundbreaking concepts can be summarized into five major notions: (1) disasters are not natural but socially constructed; (2) the inherent nexus between disaster risk, development, and the environment; (3) the significance of small- and medium-sized disasters and extensive and intensive ...
At the global level, it has been suggested that pharmacogenomic technologies hold the potential to improve knowledge about neglected and orphan diseases, and to lead to the development of novel drugs that could improve global population health [13–15]. Not surprisingly, initiatives have emerged in...
Rasayana is a branch of Ayurveda (Oriental health-care system originated in India) which deals with drugs, formulations, food, and lifestyle suggestive of anti- or rather delaying aging effects. Such approaches, collectively called as Rasayana , are proclaimed to induce qualitative improvements at...
Microglia are cells in the brain that mediate inflammation, but little is known about the role of microglia in sleep following an inflammatory challenge. We hypothesized that mice with depleted microglia would sleep less following an injection of a particle that causes inflammation in the body and ...
More precisely, by using the concepts of a variational differential system, adjoint equation and a modified Legendrian duality, under simplified hypotheses, we establish a maximum principle for the considered optimal control problem. The optimal control problems with isoperimetric constraints are governed ...