顺铂或卡铂联合依托泊苷(Platinum-Etoposide,PE)方案目前是神经内分泌癌(NEC)推荐的一线治疗方案,一项纳入105名患者的多中心研究报道:无法切除NEN-G3患者【NEC(n=83)、NET-G3(n=12)、MiNEN(n=10)】接受一线化疗,客观缓解率(ORR)达58.1%,然而不同...
NET G3和NEC(尤其是LC-NEC)在形态学上鉴别诊断可能较为困难,即便使用新的额外的分析肿瘤基质的组织学标准。不单独使用Ki-67,尽管最近的一项研究显示,55%的阈值可最好地将NEC与NET G3区分开来。当形态学不明确时,免疫组化(IHC)可使用一组抗体:ATRX / DAXX(表达缺失倾向于胰腺NET),Menin(表达缺失倾向于胰腺/...
Milone的研究表明,将G3病人分为NET G3、NEC(Ki67 21-55%)和NEC(Ki67>55%)三组,预后显著不同。Thomas K在2018ASCO上建议依据ki67指数来选择化疗方案,对于Ki67<55%的病人,无论NET G3还是NEC ,CAPTEM的6个月PFS均达到77%,显著高于含铂方案的25%。欧洲的一项研究也表明,只有Ki67大于55%的NEC对含铂方案疗效...
Milone的研究表明,将G3病人分为NET G3、NEC(Ki67 21-55%)和NEC(Ki67>55%)三组,预后显著不同。Thomas K在2018ASCO上建议依据ki67指数来选择化疗方案,对于Ki67<55%的病人,无论NET G3还是NEC ,CAPTEM的6个月PFS均达到77%,显著高于含铂...
The patient died shortly after atherapeutic attempt with streptozotocin/5-fluorouracil.#This case exemplifies the unfortunate course of arapidly progressive NETG3 and highlights the limited number of effective therapies for some tumors within the relatively new cohort of NETG3 with ayet unsatisfactory ...
NECGNuclear Economics Consulting Group(Washington, DC) NECGNew England Consulting Group NECGNetwork Economics Consulting Group(Australia) NECGNear East Consulting Group(est. 1983) NECGNet Effective Coding Gain(optical networking) NECGNew England Custom Gun Service(Claremont, NH) ...
Human subjects with NEC had similar NET scores. (B,C,F) Neutrophil elastase (NE) and myeloperoxidase (MPO), both markers of neutrophil activation, increased with time in NEC animals in comparison to controls, and were reduced in animals with PAD inhibition (blue). (D,G) Quantification of ...
NET和NEC 使用不同的分期系统，具体如下：1.NEC的分期标准和同部位的癌一致。2.目前，胃肠胰NET的分期系统仅限于G1和G2肿瘤，部位不同、分期标准不同。3.NET G3的分期依据尚未明确，建议在诊断 NET G3时，详细记录肿瘤大小、浸润深度、神经脉管侵犯、淋巴结转移数目、核分裂象计数、Ki‑67阳性指数等具体...
g. Intellectual property rights The NEC Group depends on its proprietary technology, and its ability to obtain patents and other intellectual property rights covering its products, services, business models, and design and manufacturing processes. The applications for patents and the maintenance of regis...
神经内分泌肿瘤分为( )大类。A.神经内分泌瘤(NET)G2B.神经内分泌瘤(NET)G1C.神经内分泌癌(NEC)G3D.混合性腺神经内分泌癌